QTc Interval Prolongation in Pediatric and Young Adult Patients on Methadone for Cancer Related Pain.

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Summary of "QTc Interval Prolongation in Pediatric and Young Adult Patients on Methadone for Cancer Related Pain."

Methadone has been reported to prolong the corrected QT (QTc) interval and increase the risk of torsades de pointes.


Journal Details

This article was published in the following journal.

Name: Journal of pain and symptom management
ISSN: 1873-6513


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Medical and Biotech [MESH] Definitions

A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)

Registered nurses with graduate degrees in nursing who provide care to pediatric patients who are acutely or critically ill.

Transfer from pediatric to adult care.

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The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.

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