Proper insertion and topogenesis of membrane proteins in the ER depends on Sec63.

08:00 EDT 10th June 2019 | BioPortfolio

Summary of "Proper insertion and topogenesis of membrane proteins in the ER depends on Sec63."

In eukaryotic cells, biogenesis of proteins destined to the secretory pathway begins from the cytosol. Nascent chains are either co-translationally or post-translationally targeted to the endoplasmic reticulum (ER) and translocated across the membrane through the Sec61 complex. For the post-translational translocation, the Sec62/Sec63 complex is additionally required. Sec63, however, is also shown to mediate co-translational translocation of a subset of proteins, the types and characteristics of proteins that Sec63 mediates in translocation still awaits to be defined.


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This article was published in the following journal.

Name: Biochimica et biophysica acta. General subjects
ISSN: 1872-8006


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