Molecular and histological correlations in liver cancer.

08:00 EDT 10th June 2019 | BioPortfolio

Summary of "Molecular and histological correlations in liver cancer."

Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, both at the molecular and histological level. High-throughput sequencing and gene expression profiling have identified distinct transcriptomic subclasses and numerous recurrent genetic alterations, and several HCC subtypes characterized by histological features have also been identified. HCC phenotype appears to be closely related to particular gene mutations, tumor subgroups and/or oncogenic pathways. Non-proliferative tumors display a well-differentiated phenotype, and among this molecular subgroup, CTNNB1 mutated HCC constitute a homogeneous subtype with cholestasis and microtrabecular and pseudoglandular architectural patterns. Another non-proliferative subtype has a gene expression pattern close to that of mature hepatocytes (G4) and displays a steatohepatitic phenotype. In contrast, proliferative HCC are most often poorly differentiated, and noticeably include tumors with progenitor features. A novel morphological variant of proliferative HCC, designated as "macrotrabecular-massive", was recently shown to be associated with angiogenesis activation and poor prognosis. Altogether, these findings may help in the near future to translate our knowledge of HCC biology into clinical practice, and are expected to improve precision medicine for patients with this highly aggressive malignancy. This manuscript reviews the most recent data on this exciting field, and discusses the future directions and challenges ahead.


Journal Details

This article was published in the following journal.

Name: Journal of hepatology
ISSN: 1600-0641


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