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Diabetic patients often have lipid metabolism disorders, which can lead to life-threatening complications. In this study, we investigated the regulatory effects of polysaccharides extracted from Arctium lappa L. on lipid metabolism in diabetic rats. We constructed a diabetes mellitus mouse model with streptozocin, and treated the rats with A. lappa L. polysaccharide. The body weight analysis showed that the weight of diabetic rats significantly decreased, but the weight of the rats in the polysaccharide treatment groups increased and the ratio of liver weight to body weight also appeared the well effect (tending to normal group). Serum biochemical analysis showed that total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL), and the ratio of liver weight to body weight showed a downward trend. In addition, compared to TC/HDL, TG/HDL, and HDL/LDL, the relative content of HDL was increased. Meanwhile, we used Western blotting to detect changes in protein kinase C alpha (PKC-α), PKC-β, P-selectin, nuclear factor kappa B (NF-κB), and phosphorylated NF-kB p65 in the liver. The results showed that the A. lappa L. polysaccharides regulated lipid metabolism through the PKC/NF-κB pathway in diabetic rats.
This article was published in the following journal.
Name: International journal of biological macromolecules
Polysaccharides were extracted from the roots of Arctium lappa L. (ALPs) using response surface methodology with ultrasonication. A central composition design was used to optimize extraction parameter...
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A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.
Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.
Protein components on the surface of LIPOPROTEINS. They form a layer surrounding the hydrophobic lipid core. There are several classes of apolipoproteins with each playing a different role in lipid transport and LIPID METABOLISM. These proteins are synthesized mainly in the LIVER and the INTESTINES.
Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.
Dynamic cytoplasmic organelles found in almost all cells. They consist of a central core of LIPIDS surrounded by a phospholipid monolayer studded with surface proteins, and are involved in LIPID METABOLISM and storage.
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