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Polycyclic aromatic hydrocarbons exposure and hematotoxicity in occupational population: A two-year follow-up study.

08:00 EDT 10th June 2019 | BioPortfolio

Summary of "Polycyclic aromatic hydrocarbons exposure and hematotoxicity in occupational population: A two-year follow-up study."

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental and occupational pollutants. To date, the effect and mechanism by which PAHs exposure impaired hematopoietic system remains unclear.

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This article was published in the following journal.

Name: Toxicology and applied pharmacology
ISSN: 1096-0333
Pages: 114622

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Medical and Biotech [MESH] Definitions

Aromatic hydrocarbons that contain extended fused-ring structures.

A concave exterior region on some POLYCYCLIC AROMATIC HYDROCARBONS that have three phenyl rings in a non-linear arrangement.

POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.

A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)

A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.

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