Hepatocellular Carcinomas With Mutational Activation of Beta Catenin Require Choline and can be Detected by Positron Emission Tomography.

08:00 EDT 10th June 2019 | BioPortfolio

Summary of "Hepatocellular Carcinomas With Mutational Activation of Beta Catenin Require Choline and can be Detected by Positron Emission Tomography."

In one third of hepatocellular carcinomas (HCCs), cancer cells have mutations that activate beta catenin pathway. These cells have alterations in glutamine, bile, and lipid metabolism. We investigated whether positron emission tomography (PET) imaging allows identification of altered metabolic pathways that might be targeted therapeutically.


Journal Details

This article was published in the following journal.

Name: Gastroenterology
ISSN: 1528-0012


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Medical and Biotech [MESH] Definitions

A catenin that binds F-ACTIN and links the CYTOSKELETON with BETA CATENIN and GAMMA CATENIN.

A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.

A multi-functional catenin that is highly homologous to BETA CATENIN. Gamma catenin binds CADHERINS and helps link their cytoplasmic tails to ACTIN in the CYTOSKELETON via ALPHA CATENIN. It is also found in DESMOSOMES where it mediates the link between DESMOSOMAL CADHERINS and DESMOPLAKIN.

Biochemical identification of mutational changes in a nucleotide sequence.

A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.

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