Advertisement

Topics

miR-146a inhibits biofilm-derived Cutibacterium acnes induced inflammatory reactions in human keratinocytes.

08:00 EDT 10th June 2019 | BioPortfolio

Summary of "miR-146a inhibits biofilm-derived Cutibacterium acnes induced inflammatory reactions in human keratinocytes."

Acne is a chronic inflammatory skin disorder that often involves the formation of C. acnes biofilms. Several microRNAs (miRNAs) are known to be involved in inflammatory responses. However, it is unknown whether miRNAs play a role in the inflammatory reaction triggered by C. acnes biofilm. Here we investigated the role of miR-146a in biofilm-derived C. acnes induced inflammatory responses. Increased expressions of miR-146a and toll-like receptor (TLR) 2 were detected in acne lesions. In presence of biofilm-derived C. acnes, TLR2 and its downstream NF-kB and mitogen-activated protein kinase (MAPK) pathways were activated in keratinocytes. Subsequently, miR-146a was up-regulated in these cells along with induction of IL-6, IL-8, and TNF-α. Further, our data indicated that miR-146a could directly bind the 3'-untranslated region (3'-UTR) of IL-1 receptor associated kinase 1 (IRAK1) and TNF receptor-associated factor 6 (TRAF6), and suppress their expression, leading to inhibition of biofilm-derived C. acnes induced activation of NF-kB, p38, and Erk1/2 pathways. Overall, our results indicate that biofilm-derived C. acnes induces miR-146a, which can down-regulate the production of IL-6, -8, and TNF-α in acne inflammation by inhibiting TLR2/IRAK1/TRAF6/NF-κB and MAPK pathways.

Affiliation

Journal Details

This article was published in the following journal.

Name: The Journal of investigative dermatology
ISSN: 1523-1747
Pages:

Links

DeepDyve research library

PubMed Articles [19858 Associated PubMed Articles listed on BioPortfolio]

Cutibacterium acnes in primary reverse shoulder arthroplasty: from skin to deep layers.

The aim of this study was to determine the presence of Cutibacterium acnes (formerly Propionibacterium acnes) on the skin and in deep tissue in a real clinical scenario of primary reverse shoulder art...

Prospects of acne vaccines targeting secreted virulence factors of Cutibacterium acnes.

Acne vulgaris afflicts many people, and despite the multitude of the anti-acne products on the market, there is still no effective treatment that can prevent and cure this disease. The severity of acn...

Short lipopeptides specifically inhibit the growth of Propionibacterium acnes with antibacterial and anti-inflammatory dual action.

Propionibacterium acnes (P. acnes) is a Gram-positive bacterium associated with the skin disorder acne. In this study, considering the importance of fatty acids in the life habitat of P. acnes, we tes...

Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease.

Identifying regulatory mechanisms that influence inflammation in metabolic tissues is critical for developing novel metabolic disease treatments. Here, we investigated the role of microRNA-146a (miR-1...

Clonal diversity of Cutibacterium acnes (formerly Propionibacterium acnes) in prosthetic joint infections.

Prosthetic joint infections (PJIs) are rare but feared complications following joint replacement surgery. Cutibacterium acnes is a skin commensal that is best known for its role in acne vulgaris but c...

Clinical Trials [7141 Associated Clinical Trials listed on BioPortfolio]

Cutibacterium Acnes in Bone and Joint Infections

Prosthetic Joint Infections (PJIs) are increasing with the use of orthopedic devices on an ageing population. Cutibacterium acnes is a commensal organism that plays an important role in th...

Chronic Infections on Articular Prostheses With C. Acnes Diagnosed by Specific PCR

Osteaoarticular infection due to C. acnes are known to be of late onset, causing chronic infection possibly pauci-symptomatic. Osteaoarticular infection due to C. acnes represents a diagno...

Comparison of Biofilm Characteristics Between an in Situ Biofilm Model of Supragingival Plaque and Natural Teeth

The purpose of this study is to determine in situ the bacterial viability, thickness and bacterial diversity of a biofilm formed on different substrates in comparison to a naturally tooth-...

Propionibacterium Acnes in Shoulder Arthroplasty

The investigator's plan to determine whether pre-operative skin preparation with hydrogen peroxide alters rates of P acnes culture positivity. They hypothesize that pre-operative skin prep...

Does the Disinfection of the Subcutaneous Tissue Reduce the Contamination of the Operative Field by P. Acnes During Primary Shoulder Surgery?

Propionibacterium acnes is a pathogen frequently identified during postoperative infections of the shoulder. A recent study has shown that P. acnes is likely to be disseminated in the oper...

Medical and Biotech [MESH] Definitions

A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.

A COAGULASE-negative species of STAPHYLOCOCCUS found on the skin and MUCOUS MEMBRANE of warm-blooded animals. Similar to STAPHYLOCOCCUS EPIDERMIDIS and STAPHYLOCOCCUS HAEMOLYTICUS, it is a nosocomial pathogen in NICU settings. Subspecies include generally antibiotic susceptible and BIOFILM negative capitis and antibiotic resistant and biofilm positive urealyticus isolates.

An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.

A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.

A bacteria isolated from normal skin, intestinal contents, wounds, blood, pus, and soft tissue abscesses. It is a common contaminant of clinical specimens, presumably from the skin of patients or attendants.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topics

Acne
Acne is a common skin condition that causes spots to develop on the skin, usually on the face, back and chest..  The spots can range from blackheads and whiteheads which are often mild, to inflamed pus-filled pustules and cysts, which can be severe ...

Dermatology
Acne Dermatology Eczema Psoriasis Wound Care Dermatology is the medical specialty concerned with the diagnosis and treatment of skin disorders (Oxford Medical Dictionary). As well as studying how the skin works, dermatology covers...


Searches Linking to this Article