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Acne is a chronic inflammatory skin disorder that often involves the formation of C. acnes biofilms. Several microRNAs (miRNAs) are known to be involved in inflammatory responses. However, it is unknown whether miRNAs play a role in the inflammatory reaction triggered by C. acnes biofilm. Here we investigated the role of miR-146a in biofilm-derived C. acnes induced inflammatory responses. Increased expressions of miR-146a and toll-like receptor (TLR) 2 were detected in acne lesions. In presence of biofilm-derived C. acnes, TLR2 and its downstream NF-kB and mitogen-activated protein kinase (MAPK) pathways were activated in keratinocytes. Subsequently, miR-146a was up-regulated in these cells along with induction of IL-6, IL-8, and TNF-α. Further, our data indicated that miR-146a could directly bind the 3'-untranslated region (3'-UTR) of IL-1 receptor associated kinase 1 (IRAK1) and TNF receptor-associated factor 6 (TRAF6), and suppress their expression, leading to inhibition of biofilm-derived C. acnes induced activation of NF-kB, p38, and Erk1/2 pathways. Overall, our results indicate that biofilm-derived C. acnes induces miR-146a, which can down-regulate the production of IL-6, -8, and TNF-α in acne inflammation by inhibiting TLR2/IRAK1/TRAF6/NF-κB and MAPK pathways.
This article was published in the following journal.
Name: The Journal of investigative dermatology
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A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
A COAGULASE-negative species of STAPHYLOCOCCUS found on the skin and MUCOUS MEMBRANE of warm-blooded animals. Similar to STAPHYLOCOCCUS EPIDERMIDIS and STAPHYLOCOCCUS HAEMOLYTICUS, it is a nosocomial pathogen in NICU settings. Subspecies include generally antibiotic susceptible and BIOFILM negative capitis and antibiotic resistant and biofilm positive urealyticus isolates.
An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.
A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
A bacteria isolated from normal skin, intestinal contents, wounds, blood, pus, and soft tissue abscesses. It is a common contaminant of clinical specimens, presumably from the skin of patients or attendants.
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