CsF-Mediated In-situ Desilylation of TMS-Alkynes for Sonogashira Reaction.

08:00 EDT 13th June 2019 | BioPortfolio

Summary of "CsF-Mediated In-situ Desilylation of TMS-Alkynes for Sonogashira Reaction."

A practical, mild set of conditions for the Sonogashira reaction utilizing CsF-mediated in-situ TMS-alkyne desilylation followed by Sonogashira coupling has been developed for the synthesis of a variety of alkynyl benzenes and heteroarenes in good to excellent yields. This methodology demonstrates excellent functional group tolerance, and simple purification which allows large-scale industrial application. This one-pot protocol enables a high-yielding Sonogashira coupling with volatile alkynes by avoiding challenging isolation of free alkynes.


Journal Details

This article was published in the following journal.

Name: The Journal of organic chemistry
ISSN: 1520-6904


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