Track topics on Twitter Track topics that are important to you
Hydrogen sulfide (H2S) is an important signalling molecule whose up- and down-regulation have specific biological consequences. Although significant advances in H2S up-regulation, via the development of H2S donors, have been achieved in recent years, precise H2S down-regulation in biological systems is still challenging. The lack of potent and specific inhibitors for H2S-producing enzymes contributes to this problem. We expect the development of H2S scavengers is an alternative approach to address this problem. Since H2S's chemical sensors and scavengers share almost the same criteria, we have constructed a H2S sensor database, which summarizes key parameters of all reported chemical sensors. Data-driven analysis led to the selection of 30 potential scavenger compounds. Further evaluation of these compounds identified a group of promising scavengers, based on the sulfonyl azide template. The efficiency of these scavengers in both in vitro and in vivo experiments was demonstrated.
This article was published in the following journal.
Name: Angewandte Chemie (International ed. in English)
We report here the effects of hydrogen sulfide (sulfide), that accumulates in ETHE1 deficiency, in rat cerebellum. Sulfide impaired electron transfer and oxidative phosphorylation. Sulfide also induce...
In order to further improve the photocatalytic performance of the semiconductor photocatalyst, a photocatalytic hydrogen production performance was measured using a bimetallic sulfide photocatalyst. O...
Hemoglobin in its ferryl form oxidizes hydrogen sulfide and is transformed to sulfhemoglobin, where the sulfur is inserted covalently at the heme edge. Shown here is evidence that-as previously propos...
To investigate the effect of exogenous hydrogen sulfide (HS) on intestinal mucosal barrier after cardiopulmonary resuscitation (CPR) in cardiac arrest (CA) rabbits.
Recent studies reported that hydrogen sulfide (HS) is an effective agent for the prevention and treatment of acute lung injury (ALI). But the underlying mechanisms have not been understood clearly. In...
Acute myocardial infarction (AMI) can cause heart failure, an irregular heartbeat, cardiogenic shock, or cardiac arrest. It is the major cause of morbidity and mortality in the general pop...
Oral malodor is a common condition. In most cases this condition results from the proteolytic activity of anaerobic oral bacteria. These bacteria produce volatile sulfide compounds which a...
To determine the effectiveness of combining different concentrations of hydrogen peroxide and carbamide used during tooth bleaching.
This study is a placebo-controlled, double-blind trial that will investigate the safety and tolerability of molecular hydrogen, a promising antioxidant agent, in patients with early-stage ...
This study suggested that hydrogen has a potential as an effective and safe therapeutic agent on cGVHD.
A NADPH-dependent oxidase that reduces hydrogen sulfite to HYDROGEN SULFIDE. It is found in many microoganisms.
Polymers of N-SUBSTITUTED GLYCINES containing chiral centers at the a-position of their side chains. These oligomers lack HYDROGEN BONDING donors, preventing formation of the usual intrachain hydrogen bonds but can form helices driven by the steric influence of chiral side chains.
A crystalline compound used as a laboratory reagent in place of HYDROGEN SULFIDE. It is a potent hepatocarcinogen.
A genus of phototrophic, obligately anaerobic bacteria in the family Chlorobiaceae. They are found in hydrogen sulfide-containing mud and water environments.
A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...