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The Exposome in Atopic Dermatitis.

08:00 EDT 13th June 2019 | BioPortfolio

Summary of "The Exposome in Atopic Dermatitis."

Atopic dermatitis (AD) is a complex inflammatory disorder with multiple interactions between genetic, immune and external factors. The sum of external factors that an individual is exposed to throughout their lifetime is termed the exposome. The exposome spans multiple domains from population to molecular levels and, in combination with genetic factors, holds the key to understanding the phenotypic diversity seen in AD patients. Exposomal domains are categorised into non-specific (human and natural factors affecting populations), specific (e.g. humidity, ultraviolet radiation, diet, pollution, allergens, water hardness) and internal (cutaneous and gut microbiota and host cell interaction) exposures. The skin, as the organ that most directly interacts with and adapts to the external environment is a prime target for exploration of exposomal influences on disease. Given the well-recognised physical environmental influences on AD, this condition could be much better understood through insightful exposomal research. In this narrative review, we examine each domain in turn, highlighting current understanding of the mechanisms by which exposomal influences modulate AD pathogenesis at distinct points in time. We highlight current approaches to exposome modification in AD and other allergic disease and propose future directions for exposome characterisation and modification using novel research techniques. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: Allergy
ISSN: 1398-9995
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