Advertisement

Topics

The Risk of Cytomegalovirus Infection after Treatment of Acute Rejection in Renal Transplant Recipients.

08:00 EDT 13th June 2019 | BioPortfolio

Summary of "The Risk of Cytomegalovirus Infection after Treatment of Acute Rejection in Renal Transplant Recipients."

The risk of cytomegalovirus infection (CMV) after rejection treatment is poorly understood. To investigate this, we conducted a case/control(1:2) analysis of adult renal-transplant recipients between 1/1/2005-12/31/2015 via incidence-density sampling and survival analysis. Our objective was to evaluate the association of prior acute-rejection with subsequent CMV, including epidemiology and outcomes. There were 2481 eligible renal-transplants within the study period and 251 distinct CMV infections. Despite the use of antiviral prophylaxis rejection was a significant risk factor for CMV on unadjusted (HR 1.73(1.34,2.24),p<0.05) and adjusted analysis (HR 1.46(1.06,2.04),p<0.05). When matching cases to controls patients with CMV had significantly more rejection prior to CMV diagnosis (26.7%vs14.2%,p<0.01). CMV was associated with a two-fold increased risk of prior rejection on unadjusted(OR 1.94,95%
CI:
1.28-2.96,p<0.01) and adjusted analysis(OR 2.16,95%
CI:
1.31-3.58,p<0.01). Patients with rejection preceding CMV had significantly increased graft loss (HR 2.89,95%
CI:
1.65-5.09,p<0.01) and mortality (HR 1.82,95%
CI:
1.12-4.24,p=0.03) as compared to those CMV cases without rejection. In conclusion, rejection is a risk factor for CMV infection that appears to persist for 1 year. Preceding rejection events increased risk of graft loss and mortality in CMV patients. Given this, prolonged surveillance monitoring for CMV after rejection may be warranted. Studies are needed investigating optimal monitoring strategies. This article is protected by copyright. All rights reserved.

Affiliation

Journal Details

This article was published in the following journal.

Name: Clinical transplantation
ISSN: 1399-0012
Pages: e13636

Links

DeepDyve research library

PubMed Articles [39963 Associated PubMed Articles listed on BioPortfolio]

Incidence and risk factors associated with cytomegalovirus infection after thetreatment of acute rejection during the first year in kidney transplant recipients receiving preemptive therapy.

The complex interaction betweencytomegalovirus (CMV) infection and acute rejection after kidney transplantation is well recognized.

Is antibody-mediated rejection in kidney transplant recipients a risk factor for developing cytomegalovirus or BK virus infection? Results from a case-control study.

Data are scarce on cytomegalovirus (CMV) and BK virus (BKV) infection after antibody-mediated rejection (ABMR).

Mannose binding lectin 2 gene polymorphisms in patients after renal transplantation with acute graft rejection.

Mannose-binding lectin (MBL) is one of the pattern-recognition soluble receptors and is responsible for complement activation via the lectin pathway, so it plays an important role in kidney transplant...

Clinical outcomes of polyvalent immunoglobulin use in solid organ transplant recipients: a systematic review and meta-analysis Part I: Kidney Transplant.

Polyvalent immunoglobulin is commonly used for desensitization and treatment of antibody-mediated rejection in kidney transplantation but its impact on other outcomes is not known. This systematic rev...

Polymerase chain reaction for detection of mucosal cytomegalovirus infection in patients with acute ulcerative colitis.

Cytomegalovirus (CMV) infection is associated with acute exacerbations of ulcerative colitis (UC) but its clinical relevance remains uncertain. The primary aim of this study was to assess the prevalen...

Clinical Trials [18971 Associated Clinical Trials listed on BioPortfolio]

Conversion to Sirolimus: Effects in Cytomegalovirus Infection Recurrence

Cytomegalovirus is the most important opportunistic infection after kidney transplant, with increased in mortality, morbidity and higher costs of transplantation. Despite the favorable eff...

Quantiferon - Cytomegalovirus (CMV) and the Prediction of CMV Infection In High Risk Solid Organ Transplant Recipients

Cytomegalovirus (CMV) is a common cause of illness in patients who have undergone a transplant. Serious infections due to CMV can affect many parts of the body including the lungs, the gut...

Mesenchymal Stem Cell Transplantation in the Treatment of Chronic ABMR

Transplant rejection is one of the biggest limitations in renal transplant procedures, where the kidney can undergo an acute, late acute, or chronic transplant rejection. With the advancem...

EBV Infection as a Risk Factor for PTLD in Pediatric and Adult Renal Transplant Recipients

Question: In which stage of an EBV-infection is a selective reduction of immunosuppressive medication reasonable to minimize the risk for PTLD, without putting the transplant recipient at...

A Cohort Study of Cytomegalovirus(CMV) Infection Among Pregnant Women and Their Newborns in China

The purpose of this study is to assess the risk of congenital cytomegalovirus (cCMV) infection in newborns born to seropositive women.

Medical and Biotech [MESH] Definitions

Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. Cytomegalovirus retinitis is a major opportunistic infection in AIDS patients and can cause blindness.

Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.

A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.

An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)

Vaccines or candidate vaccines used to prevent infection with CYTOMEGALOVIRUS.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topics

Infectious-diseases
Antiretroviral Therapy Clostridium Difficile Ebola HIV & AIDS Infectious Diseases Influenza Malaria Measles Sepsis Swine Flu Tropical Medicine Tuberculosis Infectious diseases are caused by pathogenic...

Nephrology - kidney function
Nephrology is a specialty of medicine and pediatrics that concerns itself with the study of normal kidney function, kidney problems, the treatment of kidney problems and renal replacement therapy (dialysis and kidney transplantation). Systemic conditions...

Transplantation
Organ transplantation is the moving of an organ from one body to another or from a donor site to another location on the patient's own body, for the purpose of replacing the recipient's damaged or absent organ. The emerging field of regenerative ...


Searches Linking to this Article