Phosphorylation in two discrete tau domains regulates a stepwise process leading to postsynaptic dysfunction.

08:00 EDT 13th June 2019 | BioPortfolio

Summary of "Phosphorylation in two discrete tau domains regulates a stepwise process leading to postsynaptic dysfunction."

Tau mislocalization to dendritic spines and associated postsynaptic deficits are mediated through different and non-overlapping phosphorylation sites. Tau mislocalization to dendritic spines depends upon the phosphorylation of either Ser396 or Ser404 in the C-terminus. Postsynaptic dysfunction instead depends upon the phosphorylation of at least one of five residues in the proline-rich region of tau. The blockade of both gsk3β and cdk5 is required to prevent P301L-induced tau mislocalization to dendritic spines, supporting redundant pathways that control tau mislocalization to spines.


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This article was published in the following journal.

Name: The Journal of physiology
ISSN: 1469-7793


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