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Integrative modeling of the HIV-1 ribonucleoprotein complex.

08:00 EDT 13th June 2019 | BioPortfolio

Summary of "Integrative modeling of the HIV-1 ribonucleoprotein complex."

A coarse-grain computational method integrates biophysical and structural data to generate models of HIV-1 genomic RNA, nucleocapsid and integrase condensed into a mature ribonucleoprotein complex. Several hypotheses for the initial structure of the genomic RNA and oligomeric state of integrase are tested. In these models, integrase interaction captures features of the relative distribution of gRNA in the immature virion and increases the size of the RNP globule, and exclusion of nucleocapsid from regions with RNA secondary structure drives an asymmetric placement of the dimerized 5'UTR at the surface of the RNP globule.

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This article was published in the following journal.

Name: PLoS computational biology
ISSN: 1553-7358
Pages: e1007150

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The mission of NCCIH is to define, through rigorous scientific investigation, the usefulness and safety of complementary and integrative health interventions and their roles in improving health and health care. The Center was established in 1999 and was known as NCCAM National Center of Complementary and Alternative Medicine until 2015.

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