Biologics in Acute Burn Injury.

08:00 EDT 1st July 2019 | BioPortfolio

Summary of "Biologics in Acute Burn Injury."

There have been significant advances in the care of burns over the past decade. As a result of the improved survival of burn patients, attention has shifted to the optimized management of their wounds. Traditionally, autografts have been described as the gold standard treatment in cases of deep second- and third-degree burn wounds; however, they are limited especially in large surface area burns. As such, advancements have been made in the development of biologic dressings, which attempt to mimic the function of the lost epidermis and/or dermis. The ideal biologic dressing is nontoxic, lacks antigenicity, is immunologically compatible, and is sterile. Additionally, easy storage conditions, long shelf lives, and reasonable costs are key determinants of whether biologic dressings may truly be widely used in the clinical setting. Biologic dressings serve an important role as skin substitutes in the setting of acute burn injury. This review aims to summarize the multitude of available biologic dressings and their applications.
The PubMed and Google Scholar databases were searched for the following terms either alone or in combination: "burn injury," "biologic membrane," "skin substitutes," "biosynthetic dressings," and "acellular membrane."


Journal Details

This article was published in the following journal.

Name: Annals of plastic surgery
ISSN: 1536-3708
Pages: 26-33


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PubMed Articles [10350 Associated PubMed Articles listed on BioPortfolio]

Burn induced nervous system morbidity among burn and non-burn trauma patients compared with non-injured people.

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The Relationship of Level of Education to Social Reintegration after Burn Injury: a LIBRE study.

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The effects of different burn dressings on length of telomere and expression of telomerase in children with thermal burns.

Burns are a common traumatic injury triggered by local tissue damage and a systemic response. In this study, we evaluated the effects of different burn dressings on telomere kinetics in children with ...

Childhood Burns Leading to Skeletal and Soft Tissue Deformities: A Case Report.

Postburn contracture is an undesirable sequel of burn injury which affects patients in many ways. A secondary deformity of the growing skeleton in case of pediatric burn patients is a challenging prob...

Using competing risk and multistate model to estimate the impact of nosocomial infection on length of stay and mortality in burn patients in Southeast China.

Due to the defects in skin barrier function and immune response, burn patients who survive the acute phase of a burn injury are at a high risk of nosocomial infection (NI). The aim of this study is to...

Clinical Trials [8193 Associated Clinical Trials listed on BioPortfolio]

Gait Training in Patients With Burn Injury

Twenty-four individuals with burn injury will be included in this study. Participants with burn injury will evaluate with the following assessment tools: Demographic datas; age, gender, he...

Burn Wound Management of Betafoam® and Allevyn® Ag Dressing

This is a randomized, controlled, multi-centre, open-label phase IV study. A total of 40 patients will be enrolled in this study. Patients will be randomly assigned to Betafoam® or Allevy...

Evaluation of Gait Symmetry in Upper Extremity Burn Injuries

Thirty patients with unilateral burn injury, and 60 healthy subjects will be included in this study. Participants with burn injury will evaluate with the following assessment tools: Demogr...

Module on Preventing Fire, Burns and Scalds Injury Among Children

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Medical and Biotech [MESH] Definitions

Pulmonary injury following the breathing in of toxic smoke from burning materials such as plastics, synthetics, building materials, etc. This injury is the most frequent cause of death in burn patients.

Specialized hospital facilities which provide intensive care for burn patients.

Abrupt reduction in kidney function defined as an absolute increase in serum CREATININE of more than or equal to 0.3. mg/dl, a percentage increase in serum creatinine of more than or equal to 50%, or a reduction in urine output. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.

A rare but serious transfusion-related reaction in which fluid builds up in the lungs unrelated to excessively high infusion rate and/or volume (TRANSFUSION-ASSOCIATED CIRCULATORY OVERLOAD). Signs of Transfusion-Related Acute Lung Injury include pulmonary secretions; hypotension; fever; DYSPNEA; TACHYPNEA; TACHYCARDIA; and CYANOSIS.

Sudden liver failure in the presence of underlying compensated chronic LIVER DISEASE (e.g., LIVER CIRRHOSIS; HEPATITIS; and liver injury and failure) due to a precipitating acute hepatic insult.

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