Track topics on Twitter Track topics that are important to you
The photodynamic impact of water-soluble zwitterionic zinc phthalocyanines (ZnPc1-4) was studied on pathogenic bacterial strains after specific light exposure (LED 665 nm). The structural differences between the studied ZnPc1-4 are in the positions and the numbers of substitution groups as well as in the bridging atoms (sulfur or oxygen) between substituents and macrocycle. The three peripherally substituted compounds (ZnPc1-3) are tetra-2-(N-propanesulfonic acid)oxypyridine (ZnPc1), tetra-2-(N-propanesulfonic acid)mercaptopyridine (ZnPc2), and octa-substituted 2-(N-propanesulfonic acid)mercaptopyridine (ZnPc3). The nonperipherally substituted compound is tetra-2-(N-propanesulfonic acid)mercaptopyridine (ZnPc4). The uptake and localization capability are studied on Gram (+) Enterococcus faecalis and Gram (-) Pseudomonas aeruginosa as suspensions and as 48 h biofilms. Relatively high accumulations of ZnPc1-4 show bacteria in suspensions with different cell density. The compounds have complete penetration in E. faecalis biofilms but with nonhomogenous distribution in P. aeruginosa biomass. The cytotoxicity test (Balb/c 3T3 Neutral Red Uptake) with ZnPc1-4 suggests the lack of dark toxicity on normal cells. However, only ZnPc3 has a minimal photocytotoxic effect toward Balb/c 3T3 cells and a comparable high potential in the photoinactivation of pathogenic bacterial species.
This article was published in the following journal.
Name: Zeitschrift fur Naturforschung. C, Journal of biosciences
The cationic Ga(III) and Zn(II) phthalocyanines carrying N-methyl-pyridinium groups at eight peripheral β-positionshave been synthesized. These complexes are highly soluble in dimethyl sulfoxide (DMS...
Bacteria are ubiquitous throughout the earth's lower atmosphere. Bacteria, especially pathogenic bacteria, play an important role in human health. The diversity, composition, and dynamics of airborne ...
The emerging contamination of pathogenic bacteria in the soil has caused a serious threat to public health and environmental security. Therefore, effective methods to inactivate pathogenic bacteria an...
The main goal of the present study was to enhance the rhizobacterium potential in a horizontal subsurface flow constructed wetland system planted with Phragmites australis, through environmentally fri...
Despite all safety efforts, drinking and wastewater can still be contaminated by Legionella and free-living amoebae (FLA) since these microorganisms are capable of resisting disinfection treatments. A...
Diabetes is considered an oxidative stress and a chronic inflammatory disease. Coenzyme Q10 (ubiquinone) is recognized as a lipid soluble antioxidant. Ubiquinol is a reduced form of coenzy...
Atopic dermatitis (AD), a chronic and relapsing inflammatory skin disease, is associated with elevated IgE levels and Th2 responses. It is currently believed that non-pathogenic bacteria m...
Surgery in the mouth and oropharynx is performed in an area colonised by bacteria non-pathogenic and pathogenic. Antibiotics are used regularly resulting in disturbances in the intestinal...
In traditional video-fluoroscopic-swallowing study, a lipid-soluble contrast (barium sulfate) has been used more than 30 years. However, it can cause chemical pneumonitis and subsequently ...
Pediatric dilated cardiomyopathy (PDCM) is the most common form fond in children. Water-soluble coenzyme Q10 (ubiquinol) is better absorbed than lipid-soluble coenzyme Q10 (ubiquinone) and...
The presence of bacteria, viruses, and fungi in water. This term is not restricted to pathogenic organisms.
A non-pathogenic, obligate aerobic, Gram-negative species of Bdellovibrio that occurs in water and soil, as well as the intestines of birds and mammals. It can infect and lyse pathogenic GRAM-NEGATIVE BACTERIA and can function as a PROBIOTIC and ANTI-BACTERIAL AGENT.
Non-pathogenic ovoid to rod-shaped bacteria that are widely distributed and found in fresh water as well as marine and hypersaline habitats.
A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.
Water-soluble, copper-containing low molecular weight polypeptides obtained from the culture medium of Streptomyces verticillus. They are specific inhibitors of DNA synthesis in bacteria and have been found to act as antitumor agents. They have also been used against rust fungi of plants.