Alteration of the fecal microbiota in North-eastern Han Chinese population with sporadic Parkinson's disease.

08:00 EDT 11th June 2019 | BioPortfolio

Summary of "Alteration of the fecal microbiota in North-eastern Han Chinese population with sporadic Parkinson's disease."

Studies have confirmed that the gut microbiota may be involved in the pathogenesis of Parkinson's disease(PD). However, the alterations in fecal microbiome in North-eastern Han sporadic PD patients remains unknown. This case control study was conducted to explore fecal microbiota compositions in North-eastern Han sporadic PD patients. The gut microbiota composition of 10 patients with sporadic PD and over 65 age and 10 matched controls was analyzed in this study. Microbiota communities in the feces were investigated using high-throughput Illumina Miseq sequencing targeting the V3-V4 region of 16S ribosomal RNA (rRNA) gene. The structure and richness of the fecal microbiota differed between PD patients and healthy controls. We had observed that the overall composition of gut microbiota in North-eastern Han Chinese healthy and PD patients was slightly different. The abundance of the family of Bacteroides and Prevotellaceae were significantly increased in heathy controls while the abundance of Ruminococcaceae, Verrucomicrobiaceae, Porphyromondaceae, Hydrogenoanaerobacterium and Lachnospiraceae NK4A were significantly enriched in North-eastern Han Chinese patients with PD. Sporadic PD patients North-eastern Han China is accompanied by alterations in the abundance of specific gut microbes. Our findings will provide a foundation to improve our understanding the pathogenesis of PD.


Journal Details

This article was published in the following journal.

Name: Neuroscience letters
ISSN: 1872-7972
Pages: 134297


DeepDyve research library

PubMed Articles [13432 Associated PubMed Articles listed on BioPortfolio]

Characteristics of the fecal microbiota of high- and low-yield hens and effects of fecal microbiota transplantation on egg production performance.

The microbiota that resides in the digestive tract plays pivotal role in maintaining intestinal environmental stability by promoting nutrition digestion and intestinal mucosal immunity. However, wheth...

Helicobacter pylori infection associates with fecal microbiota composition and diversity.

Helicobacter (H.) pylori is the most important cause for peptic ulcer disease and a risk factor for gastric carcinoma. How colonization with H. pylori affects the intestinal microbiota composition in ...

Effectiveness of fecal microbiota transplantation for severe diarrhea after drug-induced hypersensitivity syndrome.

The aim of this study was to assess effectiveness of fecal microbiota transplantation (FMT) in treating intestinal failure associated with drug-induced hypersensitivity syndrome (DIHS).A 32-year-old C...

Gut Microbiota and Microbiota-Related Metabolites as Possible Biomarkers of Cognitive Aging.

Gut microbiota composition and functionality can influence the pathophysiology of age-related cognitive impairment and dementia, according to a large number of animal studies. The translation of this ...

An epidemiology study of fecal incontinence in adult Chinese women living in urban areas.

Fecal incontinence (FI) has been shown to be a common symptom in Western countries; however, there is few researches focusing on its epidemic condition in Chinese women. We conducted this national pop...

Clinical Trials [5803 Associated Clinical Trials listed on BioPortfolio]

Fecal Microbiota Transplantation for Ulcerative Colitis

Fecal microbiota transplantation (FMT) is a strategy that infuses a fecal suspension containing a healthy donor's microbiota into a patient's gut to restore his/her intestinal microbiome. ...

Fecal Microbiota Therapy for Recurrent Clostridium Difficile Infection

Interventional, single arm, single-centre trial to evaluate the effectiveness and safety of fecal microbiota therapy (FMT) in the investigators population.

Fecal Microbiota Transplantation for Epilepsy

Increasing evidences showed the microbiota effects on neuropsychiatric disorders. This clinical trial aims to evaluate the efficacy and safety of fecal microbiota transplantation for epile...

Fecal Microbiota Transplant National Registry

A national data registry of patients receiving fecal microbiota transplantation (FMT) or other gut-related-microbiota products designed to prospectively assess short and long-term safety a...

Low Sulfur Fecal Transplant for Ulcerative Colitis

The purpose of this study is to evaluate the engraftment of donor microbiota's sulfate reducing bacteria (SRB) in subjects with active ulcerative colitis (UC) following sequential fecal mi...

Medical and Biotech [MESH] Definitions

Transfer of GASTROINTESTINAL MICROBIOTA from one individual to another by infusion of donor FECES to the upper or lower GASTROINTESTINAL TRACT of the recipient.

A form of arboviral encephalitis (primarily affecting equines) endemic to eastern regions of North America. The causative organism (ENCEPHALOMYELITIS VIRUS, EASTERN EQUINE) may be transmitted to humans via the bite of AEDES mosquitoes. Clinical manifestations include the acute onset of fever, HEADACHE, altered mentation, and SEIZURES followed by coma. The condition is fatal in up to 50% of cases. Recovery may be marked by residual neurologic deficits and EPILEPSY. (From Joynt, Clinical Neurology, 1996, Ch26, pp9-10)

A kingdom in the eastern Himalayas on the northeast border of India, bounded on the north by Tibet, on the east by Assam, on the south by Assam and West Bengal, and on the west by Sikkim and Tibet. From 1720 to 1970 it was under Chinese or Indian domination. In 1971 it became a member of the United Nations. The name comes from the Sanskrit bhota, the name for Tibet, + anta, end, with reference to its location at the southern extremity of Tibet. (From Webster's New Geographical Dictionary, 1988, p144 & Room, Brewer's Dictionary of Names, 1992, p64)

Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.

A geographical area of the United States with no definite boundaries but comprising northeastern Alabama, northwestern Georgia, northwestern South Carolina, western North Carolina, eastern Kentucky, eastern Tennessee, western Virginia, West Virginia, western Maryland, southwestern Pennsylvania, southern Ohio, and southern New York.

Quick Search

DeepDyve research library

Relevant Topics

Parkinson's Disease
Parkinson's is a progressive neurological condition, affecting one person in every 500, 95% of which are over 40. It is caused by degeneration of more than 70% of the substantia nigra, which depletes the dopamine (the neurotransmitter involved in pro...

DNA sequencing
DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule. During DNA sequencing, the bases of a small fragment of DNA are sequentially identified from signals emitted as each fragment is re-synthesized from a ...

Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Searches Linking to this Article