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Effects of huoxin formula on the arterial functions of patients with coronary heart disease.

07:00 EST 1st December 2019 | BioPortfolio

Summary of "Effects of huoxin formula on the arterial functions of patients with coronary heart disease."

Huoxin formula is a Traditional Chinese Medicine for coronary heart disease (CHD) treatment. To explore the therapeutic mechanism of the Huoxin formula on arterial functions in CHD patients. Fifty-eight CHD patients receiving cardiovascular drugs including β-receptor blocker, statins, and antiplatelet medications or others were randomized into intervention [additionally 13.5 g Huoxin formula granules dissolved in 150 mL warm water per time, twice a day ( = 30)] and control [only cardiovascular drugs ( = 28)] groups. Serum biomarkers (hs-CRP, IL-18, IL-17, TNF-α, MMP-9), and cardiovascular indicators of the common and internal carotid arteries (ICAs) were monitored before and after the treatments. After 3 months of treatment, the increases of intima-media thicknesses (IMT) of the left and right common carotid arteries (CCAs) as well as of the left and right ICAs and the increases of the left and right cardio-ankle vascular index were all significantly (all  < 0.001) less in the intervention than in control group (all  < 0.001). Serum concentrations reductions of hs-CRP, IL-18, IL-17 and MMP9 (all  < 0.001) levels were higher in the intervention compared to the control group, which correlated with the changes of left ICA (hs-
CRP:
 = 0.581,  = 0.009; IL-18:  = 0.594,  = 0.007; IL-17:  = 0.575,  0.006). Since the Huoxin formula improved arterial functions and reduced inflammatory factor activities in CHD patients, a large-scale clinical trial is warranted.

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This article was published in the following journal.

Name: Pharmaceutical biology
ISSN: 1744-5116
Pages: 13-20

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