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SLUG/HIF1-α/miR-221 regulatory circuit in endometrial cancer.

08:00 EDT 17th June 2019 | BioPortfolio

Summary of "SLUG/HIF1-α/miR-221 regulatory circuit in endometrial cancer."

The pathogenesis of endometrial cancer (EC) involves many regulatory pathways including transcriptional regulatory networks supported by transcription factors and microRNAs only in part known. The aim of this retrospective study was to explore the possible correlation in the EC microenvironment between master regulators of complex phenomena such as steroid responsiveness through estrogen receptor alpha (ERα) and progesterone receptor (PR), epithelial-to-mesenchymal transition (supported by SLUG transcription factor), hypoxia (with hypoxia inducible factor-1 alpha, HIF-1α), and obesity that has been recognized as a EC risk factor.

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This article was published in the following journal.

Name: Gene
ISSN: 1879-0038
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Medical and Biotech [MESH] Definitions

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The extension of endometrial tissue (ENDOMETRIUM) into the MYOMETRIUM. It usually occurs in women in their reproductive years and may result in a diffusely enlarged uterus with ectopic and benign endometrial glands and stroma.

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