Enrichment of polymethoxyflavones from Citrus reticulata 'Chachi' peels and their hypolipidemic effect.

08:00 EDT 7th June 2019 | BioPortfolio

Summary of "Enrichment of polymethoxyflavones from Citrus reticulata 'Chachi' peels and their hypolipidemic effect."

In the present study, a simple and efficient method based on orthogonal experimental design and macroporous resin chromatography was established for the first time for enrichment of polymethoxyflavones (PMFs) from the peels of Citrus reticulata 'Chachi' (CRC). The optimum conditions of extraction and enrichment process were as follows: use of a liquid to solid ratio of 1 to 14, two-hour extraction time repeated twice with 70% ethanol; use of HPD-450 macroporous resin, wash solvent of purified water and 25% aqueous ethanol, and 70% aqueous ethanol as desorption solvent. The purity of PMFs in the resulting extract reached 62.26%. Our data indicate that the PMFs purified could potently alleviate high-fat diet-induced hyperlipidaemia. The PMFs were nontoxic as determined by acute toxicity test. The method established was suitable for large-scale separation of PMFs from CRC peels and the PMFs might be developed as an anti-hyperlipidaemia agent or dietary supplement.


Journal Details

This article was published in the following journal.

Name: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
ISSN: 1873-376X
Pages: 226-232


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Medical and Biotech [MESH] Definitions

A flavanone glycoside found in CITRUS fruit peels.

A plant genus of the family LAMIACEAE. The common names of beebalm or lemonbalm are also used for MELISSA. The common name of bergamot is also used for Citrus bergamia (CITRUS).

A plant genus of the family RUTACEAE. They bear the familiar citrus fruits including oranges, grapefruit, lemons, and limes. There are many hybrids which makes the nomenclature confusing.

A plant species of the genus CITRUS, family RUTACEAE that provides the familiar orange fruit which is also a source of orange oil.

A plant species of the genus CITRUS, family RUTACEAE that provides the familiar lime fruit. Its common name of lime is similar to the limetree (TILIA).

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