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Passive limb movement or limb muscle stretch in humans and animals are common experimental strategies used to investigate activation of the muscle mechanoreflex independent of contraction-induced metabolite production. Cyclooxygenase (COX) metabolites, however, are produced by skeletal muscle stretch in vitro and have been found to impact various models of mechanoreflex activation. Whether COX metabolites influence the decerebrate rat triceps surae muscle stretch mechanoreflex model remains unknown. We examined the effect of rat triceps surae muscle stretch on the interstitial concentration of the COX metabolite prostaglandin E2 (PGE2). Four minutes of both static and dynamic triceps surae muscle stretch increased interstitial PGE2 concentration above baseline values (static: ↑38%, p=0.01, dynamic: ↑56%, p<0.01, n=10). The four-minute protocol was required to collect enough microdialysate fluid for PGE2 detection. The finding that skeletal muscle stretch in vivo was capable of producing COX metabolites prompted the hypothesis that the COX inhibitor indomethacin (1 mg/kg, i.a.) would reduce the pressor and cardioaccelerator responses evoked during 30 seconds (the duration most commonly used in the rat mechanoreflex model) of static and dynamic rat triceps surae muscle stretch. We found that indomethacin had no effect (p>0.05, n=9) on the pressor or cardioaccelerator responses during 30 seconds of either static or dynamic stretch. We conclude that, despite skeletal muscle stretch-induced reductions in blood flow and the possibility of increased COX metabolite concentration, COX metabolites do not activate or sensitize thin fiber muscle afferents stimulated during 30 seconds of static or dynamic mechanoreflex activation in healthy rats.
This article was published in the following journal.
Name: American journal of physiology. Regulatory, integrative and comparative physiology
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A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2.
The interference with or prevention of a behavioral or verbal response even though the stimulus for that response is present; in psychoanalysis the unconscious restraining of an instinctual process.
Tendency toward a lessened strength of response due to practice or activity. It is independent of the effect of reward and is a direct function of time interval since the last response and the number of preceding responses.
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
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