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Most of the investigations on regulatory T cells (Treg) have focused on CD4CD25Foxp3 Treg cells. Although new subsets of these cells such as CD4CD25CD127, CD4HLA-G, and CD8HLA-G Treg cells have been introduced, documents regarding these populations are limited or controversial in case of pregnancy and pre-eclampsia (PE). Here, we investigated the frequencies of the three aforementioned Treg cell subsets in the peripheral blood of non-pregnant (n = 15), healthy pregnant, and preeclamptic women (n = 17 in each group) using flow cytometry. We also assessed the ability of the isolated CD4CD25CD127 and CD4HLA-G Treg cells to suppress responder T cells proliferation and cytokine secretion using CFSE dye dilution and ELISA technique. Our results showed that the frequency of CD4CD25CD127 Treg cells was significantly lower in preeclamptic women (p = 0.001). Also, this subset negatively correlated with both systolic (R= - 0.401, p = 0.004) and diastolic (R= - 0.541, p = 0.001) blood pressures. Regarding CD4HLA-G and CD8HLA-G Treg cells, the mean percentages of these cells were significantly higher in the context of normal pregnancy (p < 0.01). Finally, our results in the functional assay experiments did not show statistically significant differences between groups (p ≥ 0.05), but they reveal a shift toward the lower suppressive capacity of CD4CD25CD127 and CD4HLA-G Treg cells in preeclamptic patients which might be clinically important. In conclusion, a significant decrease in the frequency of Treg cell subsets and also a shift toward the lower suppressive capacity of these cells in preeclamptic patients may lead to immunological maladaptation in the context of PE.
This article was published in the following journal.
Name: Journal of reproductive immunology
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T-regulatory (Treg) cells suppress the immune response to maintain homeostasis. There are 2 main subsets of Treg cells: FOXP3-positive Treg cells, which do not produce high levels of effector cytokine...
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This study evaluates the effect of erythropoietin on the number and function of regulatory T cells in adults with autoimmune hepatitis. Participants will receive a single dose of erythropo...
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CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
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The use of the GENETIC VARIATION of known functions or phenotypes to correlate the causal effects of those functions or phenotypes with a disease outcome.
Gradual bilateral hearing loss associated with aging that is due to progressive degeneration of cochlear structures and central auditory pathways. Hearing loss usually begins with the high frequencies then progresses to sounds of middle and low frequencies.
Obstetrics and gynaecology
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