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Proteome-wide signatures of function in highly diverged intrinsically disordered regions.

08:00 EDT 2nd July 2019 | BioPortfolio

Summary of "Proteome-wide signatures of function in highly diverged intrinsically disordered regions."

Intrinsically disordered regions make up a large part of the proteome, but the sequence-to-function relationship in these regions is poorly understood, in part because the primary amino acid sequences of these regions are poorly conserved in alignments. Here we use an evolutionary approach to detect molecular features that are preserved in the amino acid sequences of orthologous intrinsically disordered regions. We find that most disordered regions contain multiple molecular features that are preserved, and we define these as 'evolutionary signatures' of disordered regions. We demonstrate that intrinsically disordered regions with similar evolutionary signatures can rescue function , and that groups of intrinsically disordered regions with similar evolutionary signatures are strongly enriched for functional annotations and phenotypes. We propose that evolutionary signatures can be used to predict function for many disordered regions from their amino acid sequences.

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Name: eLife
ISSN: 2050-084X
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Medical and Biotech [MESH] Definitions

Functional proteins that do not have unique, stable, folded, three-dimensional native structures or that possess non-ordered regions under physiological conditions. They are characterized by extraordinary structural flexibility and plasticity, which enable them to adopt different conformations in response to different stimuli or different interactions.

Methods, procedures, and tests performed to diagnose disease, disordered function, or disability.

A group of homologous proteins which form the intermembrane channels of GAP JUNCTIONS. The connexins are the products of an identified gene family which has both highly conserved and highly divergent regions. The variety contributes to the wide range of functional properties of gap junctions.

The protein complement of an organism coded for by its genome.

The systematic study of the complete complement of proteins (PROTEOME) of organisms.

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