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Can community-based signalling behaviour in Saccharomyces cerevisiae be called quorum sensing? A critical review of the literature.

08:00 EDT 4th July 2019 | BioPortfolio

Summary of "Can community-based signalling behaviour in Saccharomyces cerevisiae be called quorum sensing? A critical review of the literature."

Quorum sensing is a well-described mechanism of intercellular signalling among bacteria that involves cell-density dependent chemical signal molecules. The concentration of these quorum sensing molecules increases proportional to cell density until a threshold value is exceeded which triggers a community-wide response. In this review we propose that intercellular signalling mechanisms can be associated with a corresponding ecological interaction type based on similarities between how the interaction affects the signal receiver and producer. Thus, we do not confine quorum sensing, a specific form of intercellular signalling, to only cooperative behaviours. Instead we define it as cell-density dependent responses which occur at a critical concentration of signal molecules and through a specific signalling pathway. For fungal species, the medically important yeast Candida albicans has a well-described quorum sensing system while this system is not well described in Saccharomyces cerevisiae, which is involved in food and beverage fermentations. The more precise definition for quorum sensing proposed in this review is used to consider the studies suggesting that S. cerevisiae may undergo intercellular signalling through quorum sensing. Through this lens, we conclude that there is a lack of evidence to support a specific signalling mechanism and a critical signal concentration of these behaviours in S. cerevisiae and thus these features require further investigation.

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This article was published in the following journal.

Name: FEMS yeast research
ISSN: 1567-1364
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A member of the Rho family of MONOMERIC GTP-BINDING PROTEINS from SACCHAROMYCES CEREVISIAE. It is involved in morphological events related to the cell cycle. This enzyme was formerly listed as EC 3.6.1.47.

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