An investigative expansion of a competing risk model for first failure site in locally advanced non-small cell lung cancer.

08:00 EDT 4th July 2019 | BioPortfolio

Summary of "An investigative expansion of a competing risk model for first failure site in locally advanced non-small cell lung cancer."

We hypothesized that gross tumor volume (GTV) of primary tumor (GTV) and nodal volumes (GTV) were predictors of first failure site in non-small cell lung cancer (NSCLC). We aimed at also comparing the prognostic model's complexity to its ability to generate absolute risk predictions with emphasis on variables available at the time of diagnosis. Three hundred and forty-two patients treated with definitive chemoradiotherapy (CRT) for adenocarcinoma (AC) or squamous cell carcinoma (SCC) in 2009-2017 were analyzed. Clinical data, standardized uptake values on FDG-PET/CT, GTV and GTV were analyzed using multivariate competing risk models. One hundred and thirty-seven patients had SCC. As first site of failure 49 had locoregional failure (LRF), 40 had distant metastasis (DM) and 24 died with no evidence of disease (NED). In 205 patients with AC, 34 had LRF, 118 had DM as first failure site and 17 died with NED. Performance status predicted LRF ( = .02) and UICC stage risk of DM ( = .05 for stage 3,  < .001 for stage 4). Adding histopathology changed predictions with much reduced risk of LRF in AC compared to SCC (HR = 0.5, 95%
(0.3-0.75),  = .001). Conversely, AC had a higher rate of DM than SCC (HR = 2.1, 95%
(1.5-3.0],  < .001). Addition of FDG metrics and tumor/nodal volume data predicted DM risk ( = .001), but with smaller impact on absolute risk compared to histopathology. Separation of GTV in nodal and tumor lesions did not improve risk predictions. We quantified the effect of adding volumetric and quantitative imaging to competing risk models of first failure site, but did not find tumor volume components to be important. Histopathology remains the simplest and most important factor in prognosticating failure patterns in NSCLC.


Journal Details

This article was published in the following journal.

Name: Acta oncologica (Stockholm, Sweden)
ISSN: 1651-226X
Pages: 1-7


DeepDyve research library

PubMed Articles [30050 Associated PubMed Articles listed on BioPortfolio]

Preoperative risk score for access site failure in ultrasound-guided percutaneous aortic procedures.

The factors associated with access site failure after ultrasound-guided percutaneous access for aortic endograft procedures remain poorly characterized. We developed a prediction model to risk stratif...

Validity of the Seattle Heart Failure Model after heart failure hospitalization.

Heart failure hospitalization is a sentinel event associated with increased mortality risk. Whether long-term heart failure risk models such as the Seattle Heart Failure Model (SHFM) accurately assess...

Incorporating the Probability of Competing Event(s) into the Preeclampsia Competing Risk Algorithm.

Prediction of survival in Asian patients hospitalized with heart failure: Validation of the OPTIMIZE-HF Risk Score (Validation of the OPTIMIZE-HF Risk Score).

Risk scores predicting in-patient mortality in heart failure patients have not been designed specifically for Asian patients. We aim to validate and recalibrate the OPTIMIZE-HF risk model for in-hospi...

Simplified end stage renal failure risk prediction model for the low-risk general population with chronic kidney disease.

Chronic kidney disease (CKD) contributes significant morbidity and mortality among Asians; hence interventions should focus on those most at-risk of progression. However, current end stage renal failu...

Clinical Trials [12602 Associated Clinical Trials listed on BioPortfolio]

AFP Model and Liver Transplantation.

Background & Aim: Presence of microvascular invasion (mvi) in the explanted liver defines a higher risk of recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT). Th...

An Observational, Cross Sectional Study to Assess the Prevalence of Chronic Kidney Disease (CKD) in Type 2 Diabetes Patients

This non-interventional, multi-centric, cross-sectional study is aimed to determine the prevalence of Chronic Kidney Disease in Indian patients with Type 2 Diabetes (T2DM). 3000 patients w...

Time Course Evolution of Cardiac Output

Fluid expansion is the first therapeutic option in patients presenting acute circulatory failure but the duration of its hemodynamic effects (persistency and time of maximal increase in ca...

Bayesian Hemodynamics Model for Personalized Monitoring of Congestive Heart Failure Patients

Heart failure (HF) is a serious and challenging syndrome. Globally 26 million people are living with this chronic disease and the prevalence is still increasing. Besides this growing numbe...

Beta-Blockers in Heart Failure: Pharmacy-level Intervention Comparison

The overall objective of the proposed pilot study is to begin evaluation of two methods for promoting adherence to guidelines for beta-blocker therapy in heart failure. The design include...

Medical and Biotech [MESH] Definitions

Undertaking a task involving a challenge for achievement or a desirable goal in which there is a lack of certainty or a fear of failure. It may also include the exhibiting of certain behaviors whose outcomes may present a risk to the individual or to those associated with him or her.

Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.

In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.

Investigative techniques used in pre-clinical and clinical research, epidemiology, chemistry, immunology, genetics, etc. They do not include techniques specifically applied to DIAGNOSIS; THERAPEUTICS; anesthesia and analgesia; SURGICAL PROCEDURES, OPERATIVE; and DENTISTRY.

A procedure whereby the body is stimulated to generate extra soft tissue by the application of stretching forces that stimulate new growth of tissue which, over a period of time, results in a 2-dimensional expansion of the tissue. The procedure is used in reconstructive surgery for injuries caused by trauma, burns, or ablative surgery. Various types of TISSUE EXPANSION DEVICES have been developed that exert stretching forces.

Quick Search

DeepDyve research library

Relevant Topics

Gilotrif (afatinib)
GILOTRIF (afatinib) is a kinase inhibitor indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L8...

Skin cancers
There are three main types of skin cancer: basal cell carcinoma, squamous cell carcinoma and malignant melanoma. Basal cell carcinoma Basal cell carcinoma, or BCC, is a cancer of the basal cells at the bottom of the epidermis. It’s very common ...

Searches Linking to this Article