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A heterologous "prime-boost" anti-PEDV immunization for pregnant sows protects neonatal piglets through lactogenic immunity against PEDV.

08:00 EDT 6th July 2019 | BioPortfolio

Summary of "A heterologous "prime-boost" anti-PEDV immunization for pregnant sows protects neonatal piglets through lactogenic immunity against PEDV."

Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea in neonatal suckling piglets with a high mortality. Maternal vaccines that can induce lactogenic immunity to protect suckling piglets via colostrums and milk are pivotal for the prevention and control of PEDV infection in neonatal suckling piglets. In this study, a group of pregnant sows were first orally immunized with coated PEDV-loaded microspheres and boosted with killed PEDV vaccines (heterologous prime-boost). It has been detected that the levels of PEDV-specific antibodies (IgG and IgA) in their sera and milks were higher than other negative groups (p < 0.001 or p < 0.05). Furthermore, it has been proved by the neutralization assay that the induced antibodies could significantly inhibit virus infection as compared to other negative groups (p < 0.01 or p < 0.05). Importantly, after PEDV challenge, more than 90% of the suckling piglets delivered by the sows in the heterologous prime-boost group were completely protected. Overall, the results show that "heterologous prime-boost" form is an efficient and effective way to provide protection for suckling piglets against PEDV through lactogenic immunity. This article is protected by copyright. All rights reserved.

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Name: Letters in applied microbiology
ISSN: 1472-765X
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Medical and Biotech [MESH] Definitions

A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.

Any immunization following a primary immunization and involving exposure to the same or a closely related antigen.

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Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).

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