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Elevated heme impairs macrophage phagocytosis in endometriosis.

08:00 EDT 1st July 2019 | BioPortfolio

Summary of "Elevated heme impairs macrophage phagocytosis in endometriosis."

Endometriosis (EMS) is a chronic inflammatory disease characterized by the presence of extrauterine endometrial tissues. It has been previously reported that the refluxed blood containing viable endometrial tissues and the defective elimination of peritoneal macrophages in the pelvic cavity may involve in EMS pathogenesis. However, the mechanism by which macrophages exhibit attenuated phagocytic capability in EMS remains undetermined. Herein, we found that heme, the byproduct of lysed erythrocytes, accumulated abnormally in the peritoneal fluid (PF) of patients with EMS (14.22μmol/L, 95% confidence interval [CI]:12.54 to 16.71), compared with the EMS-free group (9.517μmol/L, 95%
CI:
8.891 to 10.1053). This abnormal accumulation was not associated with the color of PF, the phase of the menstrual cycle or severity of the disease. The reduced phagocytic ability of peritoneal macrophage (pMφs) was observed in the EMS group. Consistently, a high concentration (30μmol/L) heme treatment impaired EMS-pMφs phagocytosis more than a low concentration (10μmol/L) heme treatment. A similar phenomenon was observed in the EMS-free control pMφs (Ctrl-pMφs) and the CD14+ peripheral monocytes (CD14+ Mos). These results indicated that a high heme concentration exhibits a negative effect on macrophage phagocytosis, which supplements the mechanism of impaired scavenger function of pMφs in EMS.

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This article was published in the following journal.

Name: Reproduction (Cambridge, England)
ISSN: 1741-7899
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An autosomal dominant porphyria that is due to a deficiency of FERROCHELATASE (heme synthetase) in both the LIVER and the BONE MARROW, the last enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include mainly neurological symptoms, rarely cutaneous lesions, and elevated levels of protoporphyrin and COPROPORPHYRINS in the feces.

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