Track topics on Twitter Track topics that are important to you
Two new prenylated acetophenone derivatives racemates, meliviticines A (1) and B (2) with unprecedented rearranged skeletons, were isolated from Melicope viticina. Subsequent chiral resolution led to the separation of two pairs of enantiomers, (±)-meliviticines A (1a/1b) and (±)-meliviticines B (2a/2b). Their structures including absolute configurations were elucidated by extensive spectroscopic data, electronic circular dichroism analysis, and X-ray crystallography. A plausible biosynthetic pathway of 1 and 2, involving ring cleavage and rearrangement of the prenylated acetophenone backbone was proposed. All the isolates showed moderate antimicrobial activities with MIC values of 25-50 μg/mL against several bacterial and fungal strains.
This article was published in the following journal.
Name: Bioorganic chemistry
Ficus carica is an Asian species of flowering plant belonging to the genus Ficus of the family Moraceae, native to Western Asia and the Middle East. Its fruits, usually known as common fig or fig, hav...
Stilbenoids are important components of foods (e.g., peanuts, grapes, various edible berries), beverages (wine, white tea), and medicinal plants. Many publications have described the anti-inflammatory...
Glycyrrhiza uralensis is the major plant source of licorice. This study was to identify bioactive compounds from the plant's leaves in order to make better use of its aerial part. An ethanol extract o...
Six new prenylated xanthones (1: -6: ) and seventeen known xanthones were isolated from extracts of leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The i...
NTRK-rearranged tumors could be treated using promising anti-TRK-targeted therapies in patients with advanced cancers including melanomas. Different targeted therapies are being developed together wit...
This is a phase II, multi-center, single arm study of lorlarinib as a single agent in patients with ROS1-rearranged advanced NSCLC.
This is a Phase 2 clinical trial designed to obtain data on relationships between potentially therapeutic doses of n-3 HUFA (highly unsaturated fatty acids) and their bioactive molecular d...
This study will be conducted to assess the safety and tolerability of BOS172738 when administered to patients with advanced solid tumors with rearranged during transfection (RET) gene alte...
Subepithelial connective tissue grafts (SCTG) are accepted as the gold standard in covering denuded root surfaces. Combining enamel matrix derivatives (EMD) with periodontoplasic surgical ...
This is an open-label, multicenter, single-arm, expanded access study designed to provide alectinib to patients with anaplastic lymphoma kinase-rearranged (ALK-rearranged) non-small cell l...
Derivatives of the simplest aromatic ketone acetophenone (of general formula C6H5C(O)CH3).
A plant genus of the family PIPERACEAE. Members contain prenylated quinones.
A plant genus of the family ASTERACEAE. Members contain TERPENES and achyrofuran, a prenylated dibenzofuran (BENZOFURANS).
A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers. Fagara species have been reclassified, most to ZANTHOXYLUM, some to Melicope or GLEDITSIA. The common name of stinkwood used for Zieria is also used for OCOTEA.
A plant genus of the family RUTACEAE. Most plants that are called Fagara are actually Zanthoxylum. Some members of Zanthoxylum are reclassified from ELEUTHEROCOCCUS, Melicope, and EVODIA. The twigs are used as dental brushing sticks (TOOTHBRUSHING).
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...