Robust synthesis of sugar-coumarin based fluorescent 1,4-disubstituted-1,2,3-triazoles using highly efficient recyclable citrate grafted β-cyclodextrin@magnetite nano phase transfer catalyst in aqueous media.

08:00 EDT 29th June 2019 | BioPortfolio

Summary of "Robust synthesis of sugar-coumarin based fluorescent 1,4-disubstituted-1,2,3-triazoles using highly efficient recyclable citrate grafted β-cyclodextrin@magnetite nano phase transfer catalyst in aqueous media."

Green synthesis of 1,4-disubstituted-1,2,3-triazoles via click reaction using nano magnetic FeO core decorated with cyclodextrin-citric acid (FeO@CD-CIT) acting as a phase transfer nanoreactor with low copper loading under ultrasonication at 40 °C, in aqueous media is described. Anchoring the surface of magnetite with cyclodextrin (CD) prevents its agglomeration and at the same time, CD provides a hydrophobic niche for lipophilic reactants while its outer hydrophilic core makes the reaction feasible in water yielding almost quantitative yield of desired products. Magnetic separation using an external magnet, recyclability and reuse (7 times), without appreciably affecting the %yield of the products are its other attractive attributes. Gram scale synthesis was also achieved with 93% yield.


Journal Details

This article was published in the following journal.

Name: Carbohydrate research
ISSN: 1873-426X
Pages: 107736


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