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The continuous and extensive use of pesticides, particularly in the field of agriculture, leads to contamination of all ecosystems (water, soil, and atmosphere). Among pesticides, fungicides constitute a larger group whose impact on the environment are still poorly studied. Difenoconazole belongs to triazole group of fungicides having high photochemical stability and have low biodegradability, which makes them persistent in water bodies. The present study focuses on the physiological and cytotoxic impact of difenoconazole fungicide on ciliated protozoa, Tetrahymena pyriformis with reference to growth, morphology, behaviour and its generation time. Morphological studies showed changes in the shape and size of T. pyriformis. Our result showed an inhibitory effect on population growth of T. pyriformis and the IC concentration was found to be 6.8 μg mL.The numbers of generations decreased and generation time was found to be extended in a concentration and time dependent manner. Difenoconazole caused significant depletion in phagocytic activity and also ultra-structural changes were observed by Transmission electron microscopy (TEM) analysis. The results indicate that the Tetrahymena toxicity assay could be used as a complementary system to rapidly elucidate the cytotoxic potential of fungicide.
This article was published in the following journal.
Name: Ecotoxicology and environmental safety
Penicillium spp. cause blue mold of stored pome fruit. These fungi reduce fruit quality and produce mycotoxins that are regulated for processed fruit products. Control of blue mold is achieved by fung...
The effect of carbohydrate (CHO) supplementation on physiological and perceptual responses to steady-state exercise has been studied in children. However, little is known about these responses to vari...
Physiological responses to temperature extremes are considered strong drivers of species' demographic responses to climate variability. Plants are typically classified as either avoiders or tolerators...
The understanding of the effect of non-enzymatic post-translational modifications on the protein structure is essential to unveil the molecular mechanisms underlying their related pathological process...
γ-Modified (i.e. (S)-aminomethyl, (S)-acetamidomethyl, (R)-4-(hydroxymethyl)triazol-1-ylmethyl and (S)-guanidinylmethyl) triplex-forming peptide nucleic acids (TFPNAs) were synthesized and the effect...
Climbing at high altitude and tolerating hypoxic environment require specific physiological adaptations. Large intersubjects differences exist regarding the ability to adapt to high altitu...
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EVAI2020_01 is a single blinded two part experimental medicine study to determine the extent to which different prime-boost combinations of model immunogens based on HIV-1 envelope protein...
The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions.
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
The study of the relationship between NUTRITIONAL PHYSIOLOGY and genetic makeup. It includes the effect of different food components on GENE EXPRESSION and how variations in GENES effect responses to food components.
The effect of environmental or physiological factors on the driver and driving ability. Included are driving fatigue, and the effect of drugs, disease, and physical disabilities on driving.
An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.
Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...
An assay is an analytic procedure for qualitatively assessing or quantitatively measuring the presence or amount or the functional activity of a target entity. This can be a drug or biochemical substance or a cell in an organism or organic sample. ...