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From insects to mammals: regulation of genome architecture in neural development.

08:00 EDT 9th July 2019 | BioPortfolio

Summary of "From insects to mammals: regulation of genome architecture in neural development."

One of the hallmarks of the metazoan genome is that genes are non-randomly positioned within the cell nucleus; in fact, the entire genome is packaged in a highly organized manner to orchestrate proper gene expression for each cell type. This is an especially daunting task for the development of the brain, which consists of an incredibly diverse population of neural cells. How genome architecture is established, maintained, and regulated to promote diverse cell fates and functions are fascinating questions with important implications in development and disease. The explosion in various biochemical and imaging techniques to analyze chromatin is now making it possible to interrogate the genome at an unprecedented resolution. Here we will focus on current advances in understanding genome architecture and gene regulation in the context of neural development.

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This article was published in the following journal.

Name: Current opinion in neurobiology
ISSN: 1873-6882
Pages: 146-156

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