Abnormal resting-state regional homogeneity in unmedicated bipolar II disorder.

08:00 EDT 30th June 2019 | BioPortfolio

Summary of "Abnormal resting-state regional homogeneity in unmedicated bipolar II disorder."

Previous studies demonstrated that patients with bipolar disorder (BD) exhibited abnormal neural activity in multiple brain regions. However, no study has been conducted to identify regional intrinsic neural activity changes in BD II. In the present study, we used the regional homogeneity (ReHo) approach to explore the regional abnormal neural activity in bipolar II disorder
One hundred unmedicated patients with BD II depression and 100 healthy controls (HC) underwent the resting-state functional magnetic resonance imaging. The ReHo values of each voxel was calculated in the whole brain. The two-sample t-test and threshold-free cluster enhancement (TFCE) correction were applied for the ReHo analysis.


Journal Details

This article was published in the following journal.

Name: Journal of affective disorders
ISSN: 1573-2517
Pages: 604-610


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Medical and Biotech [MESH] Definitions

The period of time following the triggering of an ACTION POTENTIAL when the CELL MEMBRANE has changed to an unexcitable state and is gradually restored to the resting (excitable) state. During the absolute refractory period no other stimulus can trigger a response. This is followed by the relative refractory period during which the cell gradually becomes more excitable and the stronger impulse that is required to illicit a response gradually lessens to that required during the resting state.

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