Testing for Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG) in typical MS.

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Summary of "Testing for Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG) in typical MS."

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Name: Multiple sclerosis and related disorders
ISSN: 2211-0356
Pages: 34-35


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Medical and Biotech [MESH] Definitions

A glycosylated extracellular myelin protein found on the MYELIN SHEATH of the CENTRAL NERVOUS SYSTEM. It is linked to the cell surface via a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE.

A high affinity receptor for myelin-associated inhibitors (MAIs) that include NOGO-A PROTEIN; OLIGODENDROCYTE MYELIN GLYCOPROTEIN; and MYELIN-ASSOCIATED GLYCOPROTEIN. It is expressed primarily by neurons in the brain and OLFACTORY BULBS. During embryonic development, it is expressed in the PERIPHERAL NERVOUS SYSTEM. It localizes to GROWTH CONES and may inhibit neurite outgrowth following SPINAL INJURY.

A transmembrane protein present in the MYELIN SHEATH of the CENTRAL NERVOUS SYSTEM. It is one of the main autoantigens implicated in the pathogenesis of MULTIPLE SCLEROSIS.

Proteins found in the myelin sheath. The major proteins of central nervous system myelin include: MYELIN PROTEOLIPID PROTEIN; MYELIN BASIC PROTEINS; and MYELIN-ASSOCIATED GLYCOPROTEIN. The major proteins of peripheral nervous system myelin include: MYELIN BASIC PROTEINS (myelin P1 protein and MYELIN P2 PROTEIN); MYELIN P0 PROTEIN; and MYELIN-ASSOCIATED GLYCOPROTEIN.

A myelin protein found in the periaxonal membrane of both the central and peripheral nervous systems myelin sheaths. It has a structure that is similar to members of the Ig superfamily that participate in cell adhesion. (From Siegel et al., Basic Neurochemistry, 5th ed, p132)

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An antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include microorganisms (such as bacteria, fungi, parasites, and viruses) and chemicals. Antibodies may be produc...

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