Defective WNT Signaling May Protect From Articular Cartilage Deterioration - A Quantitative Mri Study On Subjects With A Heterozygous WNT1 Mutation.

08:00 EDT 9th July 2019 | BioPortfolio

Summary of "Defective WNT Signaling May Protect From Articular Cartilage Deterioration - A Quantitative Mri Study On Subjects With A Heterozygous WNT1 Mutation."

WNT signaling is of key importance in chondrogenesis and defective WNT signaling may contribute to the pathogenesis of osteoarthritis and other cartilage diseases. Biochemical composition of articular cartilage in patients with aberrant WNT signaling has not been studied. Our objective was to assess the knee articular cartilage in WNT1 mutation-positive individuals using a 3.0T MRI unit to measure cartilage thickness, relaxation times, and texture features.


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This article was published in the following journal.

Name: Osteoarthritis and cartilage
ISSN: 1522-9653


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