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In this paper, we propose a stochastic multistage model that incorporates clonal expansion of premalignant cells and mutational events. Using the age-specific lung cancer as the test system, the proposed model is used to fit the incidence data in the Surveillance, Epidemiology, and End Results (SEER) registry. We first use the model with different numbers of mutations to fit the data of all lung cancer patients. Our results demonstrate that, although from two to six driver mutations in the genome of lung stem cells are reasonable for normal lung stem cells to become a malignant cell, three driver mutations are most likely to occur in the development of lung cancer. In addition, the models are employed to fit the data of female and male patients separately. The interesting result is that, for female patient data the best fit model contains four mutations while that for male patient data is the three-stage model. Finally, robustness analysis suggests that the decrease of cell net proliferation rates is more effective than the decrease of mutation rates in reducing the lung cancer risk.
This article was published in the following journal.
Name: Journal of theoretical biology
Lung cancer, with about 85% being non-small cell lung cancer (NSCLC), is one of the most common malignant tumors and the leading cause of cancer-related death in both men and women. Exosomes are defin...
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The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
Tumors or cancer of the LUNG.
An inbred strain of rat that is used for cancer research, particularly the study of CARCINOGENESIS
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...
Lung cancer is the uncontrolled cell growth in tissues of the lung. Originating in the lungs, this growth may invade adjacent tissues and infiltrate beyond the lungs. Lung cancer, the most common cause of cancer-related death in men and women, is respons...
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...