Meta-analysis of Toxoplasma gondii in pigs intended for human consumption in Mainland China.

08:00 EDT 9th July 2019 | BioPortfolio

Summary of "Meta-analysis of Toxoplasma gondii in pigs intended for human consumption in Mainland China."

Toxoplasma gondii, is one of the most important foodborne zoonotic pathogens, which can infect virtually all warm-blooded animals, including pigs, and causes severe illness in congenitally infected infants and even death in patients with AIDS. Pigs (Sus scrofa) are one of the most important intermediate hosts of T. gondii, and human transmission occurs through consumption of raw or poorly cooked pork. In this systematic review and meta-analysis, we searched Chongqing VIP, Wanfang, Chinese Web of Knowledge, PubMed, and ScienceDirect databases for published papers regarding Toxoplasma infection in pigs in China, from inception to Oct 29, 2017. Search strings included whether they reported the samples of more than 30 pigs and provided information that allowed us to establish the prevalence of Toxoplasma infection. Moreover, we excluded repeated studies, reviews, other host studies, as well as studies with inconsistent data, incomplete information, those that only provided prevalence data, and those outside of Mainland China. We extracted the numbers of pigs with Toxoplasma infection from the obtained studies, and calculated the pooled prevalence of Toxoplasma infection in the pigs using a random-effects model. The data of 44 articles (including data on 46,723 pigs) were compliant with the standards. The pooled prevalence of T. gondii infection in pigs in China was 29% (95% CI 24-34), with 25% (95% CI 18-32) in pigs sampled before 2010 and 28% (95% CI 21-36) in pigs sampled in 2010 or later. The pooled prevalence of T. gondii in pigs from Northeast China (20%, 95% CI 14-26) was significantly lower than those from other regions (North China: 40%, 95% CI 32-47; Northwest China: 32%, 95% CI 13-51; East China: 30%, 95% CI 20-41; and South China: 35%, 95% CI 26-45; Central China: 23%, 95% CI 14-31; Southwest China: 33%, 95% CI 15-52). The estimated pooled prevalence of T. gondii infection was 36% (95% CI 25-47, 8,018/21,892) in pigs tested by ELISA, 24% (95% CI 19-28, 4,304/18,608) in pigs examined by IHA, and 19% (95% CI 8-31, 1,041/6,223) in pigs detected by other methods. Moreover, 1,202 of 7,470 piglets were detected as T. gondii-positive, and the prevalence (17%) was lower than that in fattening pigs (25%, OR = 1.28), sows (34%, OR = 2.13), and breeding boars (35%, OR = 2.46). Our findings suggested that toxoplasmosis is common in pigs in Mainland China. It is necessary to monitor the prevalence of T. gondii in pigs, and powerful and effective regulatory measures should be undertaken to reduce human exposure to T. gondii via the consumption of pork.


Journal Details

This article was published in the following journal.

Name: Acta tropica
ISSN: 1873-6254
Pages: 105081


DeepDyve research library

PubMed Articles [26574 Associated PubMed Articles listed on BioPortfolio]

Is there any association between Toxoplasma gondii infection and depression? A systematic review and meta-analysis.

Toxoplasma gondii (T. gondii) is an obligate intracellular opportunistic parasite that is the causative agent of toxoplasmosis. This parasite accounts for mental disorders; however, the relationship b...

Genotyping of Toxoplasma gondii isolated from pigs for human consumption.

The present study aimed to isolate and genotype strains of T. gondii from pigs slaughtered for human consumption in South Brazil. Blood and tissues (heart, diaphragm, liver, tongue, and masseter) from...

Seroprevalence of Toxoplasma gondii infection in cancer patients: A systematic review and meta-analysis.

Toxoplasmosis, caused by Toxoplasma gondii, is a great public health concern in cancer patients, which can induce serious pathological effects. This systematic review and meta-analysis was performed t...

Toxoplasma gondii infection and risk of Parkinson and Alzheimer diseases: A systematic review and meta-analysis on observational studies.

In the past decade, Toxoplasma gondii infection has been recognized as a potential risk for many psychiatric and neurological disorders. We performed this systematic review and meta-analysis to evalua...

Endemicity of Toxoplasma infection and its associated risk factors in Cebu, Philippines.

Toxoplasma gondii is a single-celled intracellular apicomplexan parasite that causes toxoplasmosis. It is capable of infecting humans and nearly all warm-blooded animals including pigs, but cats are t...

Clinical Trials [8196 Associated Clinical Trials listed on BioPortfolio]

A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii Infection

To evaluate pyrimethamine as a prophylactic agent against toxoplasmic encephalitis in individuals who are coinfected with HIV and latent Toxoplasma gondii. Toxoplasmic encephalitis is a m...

Effect of Specific Anti-Toxoplasmatic Add-on Medication in Toxoplasma Gondii Seropositive Individuals With Schizophrenia or Major Depression

We investigate whether the add-on specific antitoxoplasmatic medication has positive effects in individuals with schizophrenia or major depression seropositive for Toxoplasma gondii (TG) i...

Effects of Soluble Fiber on Blood Pressure: A Meta-analysis of Randomly-controlled Trials

The present study conducted a meta-analysis of 22 randomly controlled trials to assess the effects of soluble fiber intake on blood pressure in human subjects. Using the Cochrane Handbook...

Toxoplasmic Encephalitis in Patients With AIDS. Treatment and Prevention of Relapse

To compare pyrimethamine and intravenous (IV) clindamycin vs. pyrimethamine and sulfonamides in the treatment of AIDS patients with central nervous system (CNS) Toxoplasma gondii.

Systematic Review and Meta-analysis of Cereal or Grain Consumption and Gastric Cancer

This project involved a systematic literature review of published trials of cereal or grain in relation to the risk of gastric cancer. Data was extracted from the publications on PubMed, E...

Medical and Biotech [MESH] Definitions

Meta-analysis of randomized trials in which estimates of comparative treatment effects are visualized and interpreted from a network of interventions that may or may not have been evaluated directly against each other. Common considerations in network meta-analysis include conceptual and statistical heterogeneity and incoherence.

The acquired form of infection by Toxoplasma gondii in animals and man.

A genus of protozoa parasitic to birds and mammals. T. gondii is one of the most common infectious pathogenic animal parasites of man.

Works consisting of studies using a quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc. It is often an overview of clinical trials. It is usually called a meta-analysis by the author or sponsoring body and should be differentiated from reviews of literature.

A macrolide antibiotic produced by Streptomyces ambofaciens. The drug is effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci. It is used to treat infections caused by bacteria and Toxoplasma gondii.

Quick Search

DeepDyve research library

Relevant Topics

Antiretroviral Therapy Clostridium Difficile Ebola HIV & AIDS Infectious Diseases Influenza Malaria Measles Sepsis Swine Flu Tropical Medicine Tuberculosis Infectious diseases are caused by pathogenic...

Immunoassay - ELISA
Immunoassays are quick and accurate tests to detect specific molecules. Immunoassays rely on an antibody to bind to the specific structure of a molecule. Antibodies are proteins generated by animals in response to the invasion of a foreign molecule (anti...

Searches Linking to this Article