Preparation and characterization of electrospun poly(lactic acid)-chitosan (core-shell) nanofibers with a new solvent system.

08:00 EDT 9th July 2019 | BioPortfolio

Summary of "Preparation and characterization of electrospun poly(lactic acid)-chitosan (core-shell) nanofibers with a new solvent system."

Poly(lactic acid)-chitosan (PLA-CS) core-shell nanofibers were successfully fabricated by coaxial electrospinning technique using a new solvent system for the core and shell solutions, dimethylformamide for the core solution and trifluoro-acetic acid/acetic acid (90/10 v/v) for the shell solution. The formation of the core-shell structure of the nanofibers with this new solvent system was confirmed by transmission electron microscopy (TEM) and attenuated total reflectance Fourier transform spectroscopy (ATR-FTIR). Morphology of the as-spun nanofibers was investigated by scanning electron microscopy (SEM) which showed bead-free smooth PLA-CS core-shell type nanofibers with an average diameter of 671 ± 172 nm and a broad diameter distribution. Thermogravimetric analysis (TGA) indicated that although PLA content was less than CS in the core-shell nanofibrous mat (20.7% PLA vs. 39% CS) the presence of PLA in the core of nanofibers significantly improved their mechanical properties. The PLA-CS core-shell nanofibers showed a two-stage release behavior of curcumin drug; an initial burst release followed by a sustained release, when the drug was incorporated in the core layer of nanofibers; hence it has potential applications in some biomedical areas such as wound dressing and drug delivery.


Journal Details

This article was published in the following journal.

Name: International journal of biological macromolecules
ISSN: 1879-0003


DeepDyve research library

PubMed Articles [15900 Associated PubMed Articles listed on BioPortfolio]

Acids 'generally recognized as safe' affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers.

Electrospinning of neat chitosan is currently achieved by using strong acids or organic solvents, which limits the use of chitosan nanofibers as biocompatible scaffolds for drug delivery and tissue en...

Fabrication, mechanical property and in vitro evaluation of poly (L-lactic acid-co-ε-caprolactone) core-shell nanofiber scaffold for tissue engineering.

Coaxial electrospinning, in which Poly (L-lactic acid-co-ε-caprolactone) (PLC) with different Lactic acid (LA) to caprolactone (CL) ratio (75:25 and 50:50) were employed to electrospin core-shell nan...

The synthesis and characterization of zinc-containing electrospun chitosan/gelatin derivatives with antibacterial properties.

Homogenous allocation of inorganic particles in a polymeric matrix is a challenge. In this work, we discuss electrospinning of chitosan /gelatin using CS-Si (chitosan silicone hybrids) as well as the ...

Effect of the configuration of poly(lactic acid) and content of poly(oxyethylene) blocks to the structure and functional properties of poly(lactic acid)-block-poly(oxirane)-based nanofibrous electrospun polyester-ether-urethanes used as potential drug-delivery system.

Poly(lactic acid)-block-poly(oxirane)s (PLA-b-POE) of various compositions were prepared using a one-pot approach and then extended in a reaction with l-lysine diethyl ester diisocyanate, thereby form...

Novel binary grafted chitosan nanocarrier for sustained release of curcumin.

The study deals with the synthesis and characterization of chitosan-g-Poly (Acrylic acid-co-Acrylamide) [chit-g-Poly (AA-co-Am)] for sustained release of curcumin. The formation of chit-g-Poly (AA-co-...

Clinical Trials [5420 Associated Clinical Trials listed on BioPortfolio]

Injectable POLY-L-Lactic Acid for Treatment of Hill and Valley Acne Scarring

Primary: Evaluate the degree of correction attainable with Poly-L-Lactic Acid(Sculptra) for the correction of hill and valley acne scarring Secondary: Document types and inc...

Facial Lipoatrophy Trial: Immediate Versus Deferred Injections of Poly-L-Lactic Acid for HIV Facial Lipoatrophy

This is a multi-centre, open-label, 96 week study to evaluate the safety, tolerability and extent and duration of improvement in HIV-1 infected subjects with antiretroviral induced facial ...

Efficacy and Safety of Poly-L-lactic Acid

This is a phase IV prospective, multicentre, single cohort, open-label clinical trial evaluating the efficacy and safety of Poly-L-lactic acid (Sculptra® Aesthetic) for the treatment of c...

The Emotional and Functional Benefits of Poly-L-Lactic Acid

This study will evaluates the emotional and functional benefits of Poly-L-Lactic Acid (Sculptra™), a cosmetic product used to fill defects of the skin. All participants will receive Scul...

Sculptra Aesthetic for the Treatment of Upper Knee Skin Laxity

All subjects will receive three, single-sided injections of PLLA, performed 1 month apart.

Medical and Biotech [MESH] Definitions

A species of gram-positive, rod-shaped LACTIC ACID bacteria that is frequently used as starter culture in SILAGE fermentation, sourdough, and lactic-acid-fermented types of beer and wine.

A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.

Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as diabetes mellitus, leukemia, or liver failure.

The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.

A family of proteins involved in the transport of monocarboxylic acids such as LACTIC ACID and PYRUVIC ACID across cellular membranes.

Quick Search


DeepDyve research library

Relevant Topics

Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

Wound management
Anything that breaks the skin is a wound because when the skin is broken, there's a risk of germs getting into the body and causing an infection. Follow and track Wound Care News on BioPortfolio: Wound Car...

Searches Linking to this Article