Intestinal microbiota can predict aGVHD following allogeneic hematopoietic stem cell transplantation.

08:00 EDT 9th July 2019 | BioPortfolio

Summary of "Intestinal microbiota can predict aGVHD following allogeneic hematopoietic stem cell transplantation."

The intestinal microbiome plays an important role in the development of acute graft-versus-host disease (aGVHD). However, it has been rarely reported whether intestinal microbiota could predict the development of aGVHD. Here, we conducted a prospective study of microbiota in 141 patients post-transplantation. We found that the microbiota diversity was lower in the aGVHD group compared with non-aGVHD group at day 0 and day 15±1 (P = 0.018 and 0.009, respectively). Diversity was negatively associated with conditioning intensity (P = 0.017, day 0 and P = 0.045, day 15) and β-lactam antibiotics administration (P = 0.004, day 15). Intensified conditioning and β-lactam antibiotics were associated with a lower ratio of Treg/Th17 cells at day 15 (P = 0.030, 0.047, respectively). At day 15, the levels of the inflammatory factors (TNF-α, IL-6, IL-17A, IL-1β, and LPS) were higher in the intensified conditioning group compared with the standard group (P < 0.05). AIM score was defined as microbiota diversity and gradient of the four bacterials (Lachnospiraceae, Peptostreptococcaceae, Erysipelotrichaceae, and Enterobacteriaceae) at day 15 post-transplantation. AIM score was positively correlated with aGVHD grades (r = 0.481, P < 0.001), and the AIM score could be a predictor for the development of aGVHD (II-IV a
AUC = 0.75, P < 0.001; III-IV a
AUC = 0.84, P < 0.001). These findings suggest that intestinal microbiota and conditioning might induce aGVHD by inflammatory factors and the Treg/Th17 balance. The constitution of the intestinal microbiota at neutrophil engraftment may predict the development of aGVHD.


Journal Details

This article was published in the following journal.

Name: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536


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