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Metabolic syndrome (MetS) is a cluster of risk factors such as insulin resistance among others, underlying the development of diabetes and/or cardiovascular diseases. Studies show a close relationship between cardiac dysfunction and abnormal cAMP catabolism, contributing to pathological-remodeling. Taken into consideration the importance of therapeutic enhancement of cAMP by stimulating its synthesis via suppression of PDEs, we examined their roles on cardiac dysfunction in high carbohydrate diet-induced MetS-rats. We first demonstrated significantly high expression levels of PDE3 and PDE4, the most highly expressed subtypes, together with the depressed cAMP-level in heart-tissue from MetS-rats. Second, we demonstrated these PDEs activities by using either their basal or PDE inhibitor-induced intracellular levels of cAMP and Ca2+, the transient intracellular Ca2+ changes under electrical-stimulation, isometric contractions in papillary muscle strips and some key signaling proteins (such as RyR2, PLN, PP1A and PKA) responsible for the Ca2+ homeostasis in isolated cardiomyocytes from MetS-rats. Overall, our present data demonstrated that the clear recovery in decreased basal cAMP level, increased protein expression levels of PDE3 and PDE4 as well as positive responses in the altered Ca2+ homeostasis to PDEs inhibitors can provide important insights on the roles of activated PDEs in depressed contractile activity of hearts from MetS-rats.
This article was published in the following journal.
Name: Canadian journal of physiology and pharmacology
Expensive and unsustainable fishmeal is increasingly being replaced with cheaper lipids and carbohydrates as sources of energy in aquaculture. Although it is known that the excess of lipids and carboh...
The prevalence of obesity is dramatic increased and strongly associated with cardiovascular disease. Adipokines, secreted from adipose tissues, are critical risk factors for the development of cardiom...
Stress-induced cardiac hypertrophy leads to heart failure. Our previous studies demonstrate that insulin-like growth factor-II receptor (IGF-IIR) signaling is pivotal to hypertrophy regulation. In thi...
Obesity is often associated with changes in cardiac function; however, the mechanisms responsible for functional abnormalities have not yet been fully clarified. Considering the lack of information re...
Increased global consumption of high-fat/high-calorie diet has led to higher incidence of the multifactorial cardiometabolic syndrome especially among women. The links between glucose deregulation and...
This study will examine the effects of a low carbohydrate diet versus a high carbohydrate diet on weight loss.
This is a 2-year randomized controlled trial to test the effect of dietary carbohydrates, both quality and quantity, on changes in internal body fat mass. Up to 250 women and men with obes...
The aim of the study is to investigate glycemic control during a low carbohydrate diet compared with during a high carbohydrate diet in adults with insulin pump treated type 1 diabetes.
The overall aim is to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality.
This study will compare the safety and effectiveness of a low carbohydrate diet (Atkins Diet) with a high carbohydrate diet (conventional USDA diet).
A diet that consists mainly of foods with a high content of protein and limited amounts of CARBOHYDRATES.
An indication of the contribution of a food to the nutrient content of the diet. This value depends on the quantity of a food which is digested and absorbed and the amounts of the essential nutrients (protein, fat, carbohydrate, minerals, vitamins) which it contains. This value can be affected by soil and growing conditions, handling and storage, and processing.
A diet that contains limited amounts of CARBOHYDRATES. This is in distinction to a regular DIET.
A diet rich in DIETARY CARBOHYDRATES.
A diet prescribed in the treatment of diabetes mellitus, usually limited in the amount of sugar or readily available carbohydrate. (Dorland, 27th ed)
Nephrology - kidney function
Nephrology is a specialty of medicine and pediatrics that concerns itself with the study of normal kidney function, kidney problems, the treatment of kidney problems and renal replacement therapy (dialysis and kidney transplantation). Systemic conditions...
Cardiology is a specialty of internal medicine. Cardiac electrophysiology : Study of the electrical properties and conduction diseases of the heart. Echocardiography : The use of ultrasound to study the mechanical function/physics of the h...