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RP5-1120P11.3 promotes hepatocellular carcinoma development via hsa-miR-196b-5p/WIPF2 axis.

08:00 EDT 12th July 2019 | BioPortfolio

Summary of "RP5-1120P11.3 promotes hepatocellular carcinoma development via hsa-miR-196b-5p/WIPF2 axis."

Hepatocellular carcinoma (HCC) remains a huge threat to human health although the diagnosis and treatment strategies have been improved rapidly in the past few decades. Increasing evidence has illustrated the roles of non-coding RNA and their regulatory network which plays critical roles in pathology of HCC. Here, we identified a novel long non-coding RNA, RP5-1120P11.3 that ectopically expressed in HCC. Further characterization of RP5-1120P11.3 revealed that RP5-1120P11.3 promoted proliferation and invasion of HCC while inhibited apoptosis. Importantly, our data revealed that miR-196b-5p interacted with and was regulated by RP5-1120P11.3 via a sponging mechanism. Inhibition of miR-196b-5p attenuated the phenotypes resulted from RP5-1120P11.3 inhibition. Moreover, our data showed that miR-196b-5p inhibited the expression of WIPF2 in HCC and thus illustrated a regulatory axis of RP5-1120P11.3/miR-196b-5p/WIPF2 that facilitated the progression of HCC. In addition, our data showed that RP5-1120P11.3 contributed to the xenograft generation in vivo via regulating miR-196b-5p and WIPF2. These findings suggested that RP5-1120P11.3/miR-196b-5p/WIPF2 axis is a potential target for treatment of HCC.

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This article was published in the following journal.

Name: Biochemistry and cell biology = Biochimie et biologie cellulaire
ISSN: 1208-6002
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