Novel Pyrene Excimer and Fluorogenic Probe for the Detection of Alkylating Agents.

08:00 EDT 12th July 2019 | BioPortfolio

Summary of "Novel Pyrene Excimer and Fluorogenic Probe for the Detection of Alkylating Agents."

A pyrene-containing salicylic acid derivative () was found to be low in fluorescence, but its derivative pyrene-containing methyl salicylate () was found to be highly fluorescent in aqueous solution. This derivative has been tested in solution and found to be superior in the fluorogenic assay of pharmaceutical compounds, detection of chemical warfare agents, a preliminary toxicology test, mutagenicity of medicinal compounds, and other chemical analyses, including trimethylsilyl diazomethane; alkyl bromides and iodides; a sulfur mustard mimic 2-chloroethyl ethyl sulfide; and anticancer drugs, busulfan and pipobroman. The salicylic acid derivative () was applied as a fluorogenic probe for the detection of alkylating agents by esterification and generating fluorescence at 475 nm in solutions at low concentrations.


Journal Details

This article was published in the following journal.

Name: ACS sensors
ISSN: 2379-3694


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An assay is an analytic procedure for qualitatively assessing or quantitatively measuring the presence or amount or the functional activity of a target entity.  This can be a drug or biochemical substance or a cell in an organism or organic sample. ...

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