Human myometrial artery function and endothelial cell calcium signalling are reduced by obesity: can this contribute to poor labour outcomes?

08:00 EDT 12th July 2019 | BioPortfolio

Summary of "Human myometrial artery function and endothelial cell calcium signalling are reduced by obesity: can this contribute to poor labour outcomes?"

Determining how obesity affects function in human myometrial arteries, to help understand why childbirth has poor outcomes in obese women.


Journal Details

This article was published in the following journal.

Name: Acta physiologica (Oxford, England)
ISSN: 1748-1716
Pages: e13341


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A fluorescent calcium chelating agent which is used to study intracellular calcium in many tissues. The fluorescent and chelating properties of Fura-2 aid in the quantitation of endothelial cell injury, in monitoring ATP-dependent calcium uptake by membrane vesicles, and in the determination of the relationship between cytoplasmic free calcium and oxidase activation in rat neutrophils.

A secreted angiopoietin-like protein expressed under hypoxic conditions by ENDOTHELIAL CELLS. It inhibits cell proliferation, cell migration, and tubule formation; the inactive form accumulates in the endothelial EXTRACELLULAR MATRIX, reducing vascular leakage. ANGPTL4 has direct roles in regulating glucose and lipid metabolism, as well as INSULIN SENSITIVITY, and may also function as a regulator of angiogenesis and tumorigenesis.

Endovascular reconstruction of an artery, which may include the removal of atheromatous plaque and/or the endothelial lining as well as simple dilatation. These are procedures performed by catheterization. When reconstruction of an artery is performed surgically, it is called ENDARTERECTOMY.

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A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.

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