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The structure of the extended E2 DNA-binding domain of the Bovine Papillomavirus-1.

08:00 EDT 12th July 2019 | BioPortfolio

Summary of "The structure of the extended E2 DNA-binding domain of the Bovine Papillomavirus-1."

Bovine papillomavirus proteins were extensively studied as a prototype for the human papillomavirus. Here, the crystal structure of the extended E2 DNA-binding domain of the dominant transcription regulator from the bovine papillomavirus strain 1 is described in the space group P3 21. We found two protein functional dimers packed in the asymmetric unit. This new protein arrangement inside the crystal led to the reduction of the mobility of a previously unobserved loop directly involved in the protein-DNA interaction, which was then modelled for the first time. This article is protected by copyright. All rights reserved.

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Name: Proteins
ISSN: 1097-0134
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