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Infant cholesterol and glycated hemoglobin concentrations vary widely - associations with breastfeeding, infant diet and maternal biomarkers.

08:00 EDT 12th July 2019 | BioPortfolio

Summary of "Infant cholesterol and glycated hemoglobin concentrations vary widely - associations with breastfeeding, infant diet and maternal biomarkers."

Elevated total cholesterol (TC) and glycated hemoglobin (HbA1c) are risk factors for cardiovascular disease however little is known about their determinants in infants. We aimed to describe TC and HbA1c concentrations in infants aged 8-14 months, and explore the relation between infant TC, HbA1c, breastfeeding, infant diet, and maternal TC and HbA1c.

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Journal Details

This article was published in the following journal.

Name: Acta paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227
Pages:

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Medical and Biotech [MESH] Definitions

Products of non-enzymatic reactions between GLUCOSE and HEMOGLOBIN A, occurring as a minor fraction of the hemoglobin components of human erythrocytes. Hemoglobin A1c is hemoglobin A with glucose covalently bound to the terminal VALINE of the beta chain. Glycated hemoglobin A is used as an index of the average blood sugar level over a lifetime of erythrocytes.

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An adult hemoglobin component normally present in hemolysates from human erythrocytes in concentrations of about 3%. The hemoglobin is composed of two alpha chains and two delta chains. The percentage of HbA2 varies in some hematologic disorders, but is about double in beta-thalassemia.

Minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time.

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