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Wound Healing Effect of Non-Thermal Atmospheric Pressure Plasma Jet on a Rat Burn Wound Model: A Preliminary Study.

08:00 EDT 11th July 2019 | BioPortfolio

Summary of "Wound Healing Effect of Non-Thermal Atmospheric Pressure Plasma Jet on a Rat Burn Wound Model: A Preliminary Study."

Worldwide, an estimated 6 million patients seek medical attention for burns annually. Various treatment methods and materials have been investigated and developed to enhance burn wound healing. Recently, a new technology, plasma medicine, has emerged to offer new solutions in wound care. As the development of plasma medicine has shown benefit in wound healing, we aimed to assess the effects of plasma medicine on burn wounds. To investigate the effectiveness of a non-thermal atmospheric pressure plasma jet for burn wound treatment on a brass-comb burn wound rat model. Burn wounds were made by applying a pre-heated brass comb (100 °C) for 2 minutes, which resulted in 4 full-thickness burn wounds separated by 3 interspaces. Interspaces were exposed to non-thermal atmospheric pressure plasma jet treatment for 2 minutes and morphological changes and neutrophil infiltration were monitored at 0, 4, and 7 days post-wounding. The percentage of necrotic interspace was higher in the control group than in the plasma-treated group (51.8 ± 20.5% vs. 31.5 ± 19.0%, P < 0.001). Moreover, the exposure of interspace to non-thermal atmospheric pressure plasma jet greatly reduced the number of infiltrating neutrophils. In addition, the percentage of interspace that underwent full-thickness necrosis in the plasma-treated group was smaller than that in the control group (28% vs. 67%). non-thermal atmospheric pressure plasma jet exposure on interspaces has a positive effect on burn wounds leading to wound healing by reducing burn injury progression.

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This article was published in the following journal.

Name: Journal of burn care & research : official publication of the American Burn Association
ISSN: 1559-0488
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A vascular connective tissue formed on the surface of a healing wound, ulcer, or inflamed tissue. It consists of new capillaries and an infiltrate containing lymphoid cells, macrophages, and plasma cells.

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