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Metastasis of cells from primary site to distant organs involves a series of sequential steps, and molecules responsible for all these events are understandably considered as potential targets for metastasis management. Tea polyphenols, the secondary metabolites of the tea leaf , are increasingly being studied for their antimetastatic properties. In this article, effects of green tea polyphenols (GTP) and black tea polyphenols (BTP) on the molecules and events involved in metastasis are discussed in detail. As tea is a very popular beverage, tea polyphenols are expected to be potential chemopreventive agents that can be taken with normal diet and can be nontoxic due to their natural origin. However, individual variations in metabolic pathways, bioavailability, dose, and toxicity are some important factors that can modify the effectiveness of tea polyphenols within the human system.
This article was published in the following journal.
Name: Nutrition and cancer
In the recent years, plant polyphenols have gained significant attention in oncotherapy. Accumulating evidence indicates that polyphenols have potential antitumor properties for multiple types of canc...
Metastasis involves the accumulation of genetic and epigenetic alterations leading to activation of prometastatic genes and inactivation of antimetastatic genes. Among epigenetic alterations, DNA hype...
The poor water solubility and oral bioavailability of many lipophilic polyphenols can be improved through the use of colloidal delivery systems. In this study, a pH-driven method was used to encapsula...
Dietary polyphenols may protect against breast cancer. However, it is unknown whether polyphenols reach human malignant breast tumours in molecular forms and(or) at concentrations likely to act agains...
The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of ...
The aim of this is study is to evaluate the acute effect of grape and pomegranate polyphenols in the modulation of markers of metabolic syndrome. Most of the previous works about polypheno...
Apple polyphenols are mostly acknowledged for their hypoglycaemic properties, but represent an apple active fraction with many pharmacological functions. The study aim was to examine their...
To determine whether fruit juice rich in polyphenols might increase exercise capacity and memory in healthy sedentary subjects.Both parameters might be improved because of the anti-oxidant...
The aim of this is study is to evaluate the long-term effects of grape polyphenols in the modulation of markers of metabolic syndrome. Most of the previous works about polyphenols have onl...
This project aims to leverage existing data from a large observational prospective study on dementia, the Three-City study, to investigate the relationship between intakes of polyphenols a...
Exudate from seeds of the grape plant Vitis vinifera, composed of oils and secondary plant metabolites (BIOFLAVONOIDS and polyphenols) credited with important medicinal properties.
A large class of organic compounds having more than one PHENOL group.
An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.
A plant genus of the family FABACEAE. It is the source of an herbal tea that is commonly consumed in South Africa. Members contain aspalathin and other polyphenols (PHENOLS).
The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.