Modeling the Growth of Organisms Validates a General Relation between Metabolic Costs and Natural Selection.

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Summary of "Modeling the Growth of Organisms Validates a General Relation between Metabolic Costs and Natural Selection."

Metabolism and evolution are closely connected: if a mutation incurs extra energetic costs for an organism, there is a baseline selective disadvantage that may or may not be compensated for by other adaptive effects. A long-standing, but to date unproven, hypothesis is that this disadvantage is equal to the fractional cost relative to the total resting metabolic expenditure. We validate this result from physical principles through a general growth model and show it holds to excellent approximation for experimental parameters drawn from a wide range of species.


Journal Details

This article was published in the following journal.

Name: Physical review letters
ISSN: 1079-7114
Pages: 238101


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Medical and Biotech [MESH] Definitions

Measurement of cells' substrate utilization and biosynthetic output for modeling of METABOLIC NETWORKS.

Organisms whose GENOME has been changed by a GENETIC ENGINEERING technique.

Organisms that live in water.

One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)

One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.

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