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Ruthenium-Catalyzed Synthesis of N-Methylated Amides using Methanol.

08:00 EDT 12th July 2019 | BioPortfolio

Summary of "Ruthenium-Catalyzed Synthesis of N-Methylated Amides using Methanol."

An efficient synthesis of N-methylated amides using methanol in the presence of a ruthenium(II) catalyst is realized. Notably, applying this process, tandem C-methylation and N-methylation were achieved to synthesize α-methyl N-methylated amides. In addition, several kinetic studies and control experiments with the plausible intermediates were performed to understand this novel protocol. Furthermore, detailed computational studies were carried out to understand the mechanism of this transformation.

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Name: Organic letters
ISSN: 1523-7052
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Medical and Biotech [MESH] Definitions

A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.

Unstable isotopes of ruthenium that decay or disintegrate emitting radiation. Ru atoms with atomic weights 93-95, 97, 103, and 105-108 are radioactive ruthenium isotopes.

Inorganic compounds that contain ruthenium as an integral part of the molecule.

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