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The pH of aqueous aerosols, as well as cloud and fog droplets, has an important influence on the chemistry that takes place within these unique microenvironments. Utilizing conjugate acid/base pairs to infer pH changes, we investigate, for the first time, changes in aerosol pH upon droplet coalescence. In particular, we show that the pH within individual aqueous aerosol droplets that are ~8 μm in diameter can be titrated via droplet coalescence in an Aerosol Optical Tweezer (AOT). Using sulfate/bisulfate and carbonate/bicarbonate as model systems, the pH of trapped droplets is determined before and after introduction of smaller droplets containing a strong acid. The pH change upon coalescence of the acid within the trapped droplet is calculated using Specific Ion Interaction Theory (SIT). Furthermore, we show that the pH of an individual aerosol can be manipulated along a fairly wide range of pH values, paving the way for future studies requiring rigorous pH control of aqueous aerosol.
This article was published in the following journal.
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Moving contact lines of more than two phases dictate a large number of interfacial phenomena. Despite their significance in fundamental and applied processes, the contact lines at a junction of four-p...
The simultaneous evaporation and condensation of multiple volatile components from multicomponent aerosol droplets leads to changes in droplet size, composition and temperature. Measurements and model...
The sudden expansion of gas at the outlet of the jet (pneumatic) nebulizer significantly reduces the temperature of the solution, which may provoke bronchospasm, therefore it is recommended to use mod...
Sustained dropwise condensation of water requires rapid shedding of condensed droplets from the surface. Here, we elucidate a microfluidic mechanism that spontaneously sweeps condensed microscale drop...
A phenomenon that an electric current is generated when a pedant water droplet touches an air-electrolyte solution interface is investigated in this paper. A measurement system developed in this study...
Prospective single-blind, multicenter, national, randomized, controlled trial in 15 Emergency Department to compare two ways of morphine titration. The eligible patient is included immedia...
Three different dose titration schedules are tested to find a way to reduce the titration period of lacosamide
This study examines the pharmacokinetic profile of Armstrong's proposed Epinephrine Inhalation Aerosol USP, an HFA-MDI (E004), in healthy male and female adult volunteers. Safety of E004 w...
The purpose of this study is to evaluate the safety and tolerability of a more rapid dose titration in acute schizophrenic patients compared to the conventional titration.
This study will use droplet digital PCR (ddPCR) method to quantify and track peripheral blood plasma mutant allele frequency (MAF) in MDS and AML patients before, during and after chemothe...
A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.
A quantitative form of intradermal testing for the relative allergenicity of a substance. It is used to determine the amount of an allergen that will be tolerated in ALLERGEN IMMUNOTHERAPY.
Solution titration in which the end point is read from the electrode-potential variations with the concentrations of potential determining ions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
A long-acting beta-2-adrenergic receptor agonist. It is a potent bronchodilator that may be administered orally or by aerosol inhalation.