Advertisement

Topics

Concise Review: Beta-cell dedifferentiation in type 2 diabetes.

08:00 EDT 12th July 2019 | BioPortfolio

Summary of "Concise Review: Beta-cell dedifferentiation in type 2 diabetes."

Type 2 diabetes (T2D) is caused by an inherited predisposition to pancreatic islet β-cell failure, which is manifested under cellular stress induced by metabolic overload. The decrease in the functional β-cell mass associated with T2D has been attributed primarily to β-cell death; however, studies in recent years suggested that β-cell dedifferentiation may contribute to this decline. The mechanisms linking genetic factors and cellular stress to β-cell dedifferentiation remain largely unknown. Here I evaluate the evidence for β-cell dedifferentiation in T2D, and consider experimental systems in which its mechanisms may be studied. Understanding these mechanisms may allow prevention of β-cell dedifferentiation, or induction of cell redifferentiation for restoration of the functional β-cell mass. SIGNIFICANCE
STATEMENT:
This review evaluates the evidence for ß-cell dedifferentiation in Type 2 diabetes (T2D), and considers experimental systems in which its mechanisms may be studied. Understanding these mechanisms may allow prevention of ß-cell dedifferentiation, or induction of cell redifferentiation for restoration of the functional ß-cell mass. © AlphaMed Press 2019.

Affiliation

Journal Details

This article was published in the following journal.

Name: Stem cells (Dayton, Ohio)
ISSN: 1549-4918
Pages:

Links

DeepDyve research library

PubMed Articles [36576 Associated PubMed Articles listed on BioPortfolio]

MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosis.

Current research indicates that beta cell loss in type 2 diabetes may be attributed to beta cell dedifferentiation rather than apoptosis; however, the mechanisms by which this occurs remain poorly und...

Pregnancy in human IAPP transgenic mice recapitulates beta cell stress in type 2 diabetes.

Islet amyloid polypeptide (IAPP) misfolding and toxic oligomers contribute to beta cell loss and stress in type 2 diabetes. Pregnancy-related diabetes predicts subsequent risk for type 2 diabetes but ...

The effects of incretin-based therapies on beta-cell function and insulin resistance in type 2 diabetes: a systematic review and network meta-analysis combining 360 trials.

To evaluate the comparative effects of incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 inhibitors (DPP-4Is), on beta-cell function ...

Induction of α cell-restricted Gc in dedifferentiating β cells contributes to stress-induced β-cell dysfunction.

Diabetic β cell failure is associated with β cell dedifferentiation. To identify effector genes of dedifferentiation, we integrated analyses of histone methylation as a surrogate of gene activation ...

Testing for optimal beta cell preserving treatment in Latent Autoimmune Diabetes in Adults (LADA). Results from a 21 month randomized trial.

Scarcity of randomized clinical trials in LADA makes it uncertain whether a type 1 or 2 diabetes-like treatment is optimal in preserving beta cell function. Here we compared outcome of glucagon stimul...

Clinical Trials [17370 Associated Clinical Trials listed on BioPortfolio]

Beta-Cell Transplantation in Pre-Uremic Patients With Type 1 Diabetes

To examine whether temporary immunosuppression with ATG, tacrolimus and MMF allows prolonged survival of beta cell allografts in type 1 diabetic patients with early chronic complications o...

C-peptide Concentrations in Type 2 Diabetes Treated With Insulin; is it Time to Revise the Treatment of Type 2 Diabetes

C-peptide is used to evaluate beta cell reserves. Patients with type 2 diabetes are treated with insulin for different indications. Other than beta-cell insufficiency and organ failures, i...

A Study of SIMPONI® to Arrest Beta-cell Loss in Type 1 Diabetes

The primary purpose of this study is to determine if golimumab can preserve beta-cell function in children and young adults with newly diagnosed Type 1 Diabetes (T1D).

Beta Cell Imaging During and Shortly After the Honeymoon Phase of T1D

The primary goal is to correlate beta cell mass to beta cell function from measurements during and shortly after the honeymoon phase of type 1 diabetes, to improve understanding of the cha...

LIraglutide and Beta-cell RepAir (LIBRA) Study

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by progressive deterioration in the function of the pancreatic beta-cells, which are the cells that produce an...

Medical and Biotech [MESH] Definitions

The reverse developmental process in which differentiated cells with specialized functions become undifferentiated PROGENITOR CELLS once again. Dedifferentiation and subsequent proliferation provide the basis for tissue regeneration and the formation of new stem cell lineages.

The time period before the development of symptomatic diabetes. For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2).

Autoimmune diabetes in adults with slowly progressive PANCREATIC BETA CELL failure and the presence of circulating autoantibodies to PANCREATIC ISLETS cell antigens.

A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

A single-pass transmembrane CELL SURFACE RECEPTOR that binds ADVANCED GLYCOSYLATION END PRODUCTS to mediate cellular responses to both acute and chronic vascular inflammation in conditions such as ATHEROSCLEROSIS and DIABETES MELLITUS, TYPE 2 . It also binds AMYLOID BETA PEPTIDES and the alarmins S100A12 and S100 CALCIUM BINDING PROTEIN BETA SUBUNIT.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Searches Linking to this Article