Concise Review: Beta-cell dedifferentiation in type 2 diabetes.

08:00 EDT 12th July 2019 | BioPortfolio

Summary of "Concise Review: Beta-cell dedifferentiation in type 2 diabetes."

Type 2 diabetes (T2D) is caused by an inherited predisposition to pancreatic islet β-cell failure, which is manifested under cellular stress induced by metabolic overload. The decrease in the functional β-cell mass associated with T2D has been attributed primarily to β-cell death; however, studies in recent years suggested that β-cell dedifferentiation may contribute to this decline. The mechanisms linking genetic factors and cellular stress to β-cell dedifferentiation remain largely unknown. Here I evaluate the evidence for β-cell dedifferentiation in T2D, and consider experimental systems in which its mechanisms may be studied. Understanding these mechanisms may allow prevention of β-cell dedifferentiation, or induction of cell redifferentiation for restoration of the functional β-cell mass. SIGNIFICANCE
This review evaluates the evidence for ß-cell dedifferentiation in Type 2 diabetes (T2D), and considers experimental systems in which its mechanisms may be studied. Understanding these mechanisms may allow prevention of ß-cell dedifferentiation, or induction of cell redifferentiation for restoration of the functional ß-cell mass. © AlphaMed Press 2019.


Journal Details

This article was published in the following journal.

Name: Stem cells (Dayton, Ohio)
ISSN: 1549-4918


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