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Fabrication of a Dual-Stimuli-Responsive Supramolecular Micelle from a Pillar5arene-Based Supramolecular Diblock Copolymer for Photodynamic Therapy.

08:00 EDT 12th July 2019 | BioPortfolio

Summary of "Fabrication of a Dual-Stimuli-Responsive Supramolecular Micelle from a Pillar5arene-Based Supramolecular Diblock Copolymer for Photodynamic Therapy."

A pH and thermo dual-responsive supramolecular diblock copolymer is constructed by host-guest recognition of pillar[5]arene and viologen salt. The host polymer, poly(N,N-dimethylaminoethyl methacrylate) bearing pillar[5]arene as the terminal group (P[5]A-PDMAEMA) is synthesized by atom transfer radical polymerization (ATRP). Guest polymer, ethyl viologen-ended poly(N-isopropylacrylamide) (EV-PNIPAM) is prepared by reversible addition-fragmentation chain transfer polymerization. The supramolecular diblock copolymer can be self-assembled into stable supramolecular nanoparticles in aqueous solution at 40 °C, which show excellent pH and thermo responsiveness. The nanoparticles are further applied in the encapsulation of photosensitizers (pyropheophorbide-a, PhA) for photodynamic therapy (PDT). The dual-responsive nanoparticles can efficiently release PhA in acidic environment at 25 °C. Based on the result of cell experiments, PhA-loaded nanomicelles exhibit excellent PDT efficacy and low dark toxicity toward A549 cells. Thus, this supramolecular diblock copolymer enriches the methodology of constructing stimuli-responsive drug carriers and presents a great potential in PDT.

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This article was published in the following journal.

Name: Macromolecular rapid communications
ISSN: 1521-3927
Pages: e1900240

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